Pharmacology (2) Flashcards
What are the 4 antiarrhythmic drug classes?
Class 1 - Na+ Channel Blockers
Class 2 - Beta (receptor)-Blockers
Class 3 - K+ Channel Blockers
Class 4 - Nondihydropyridine Calcium channel blockers
What parts of the cardiac action potential do each drug class inhibit?
Class 1 - Phase 0 (Na+ Channel Block)
Class 2 - Phase 4 (Beta-Blocker; inhibit sympathetic stimulation)
Class 3 - Phases 0-3 (K+ Channel Block)
Class 4- Phase 2 (Ca2+ Channel Block)
Which drugs can block the AV node? (4)
Class 2
Class 4
Adenosine
Digoxin
Lidocaine and Flecainide are which drug class type? What are their mechanisms of action? Which is strong? Weak?
Class 1
Blocks Na+ channel to slow cardiac AP and HR
Flecainide (1c) – Strong
Lidocaine (1b) – Weak
Classify & describe the mechanism of action of amiodarone. What is unique about amiodarone?
Class 3
Blocks K+ channel to increase refractory period of AP –> Lower HR
Has both rhythm and rate control
Sotalol and Dofetilide are which drug class type? What are their mechanisms of action?
Class 3
Blocks K+ channel to increase refractory period of cardiac AP –> lower HR
Classify and describe the mechanism of action of Dilitazem and Verapamil.
Class 4
Blocks Ca2+ channels to slow conduction speed (& cardiac contractility) –> lower HR.
What’s the difference between a dihydropyridine and nondihydropyridine calcium channel blocker?
Dihydropyridine - Will block Ca2+ channels on vascular smooth muscle (for HTN)
Nondihydropyridine - Will block Ca2+ channels on the heart (pacemaker cells & myocytes)
What is the effective refractory period (ERP)?
The period of time in which the cell is not excitable.
What effect do class 4 drugs have on the ECG waveform? How is this achieved?
By slowing AV node conduction velocity, you will see a prolonged PR interval.
What effect do class 4 drugs have on heart muscle contraction? How is this achieved?
They weaken heart muscle contraction. This is because blocking Ca2+ channels shortens phase 2 of the cardiac action potential which means less myocyte contraction.
Classify and describe the mechanism of action of Beta-Blockers.
Class 2
Decrease HR by blocking cardiac beta (1>2) receptors that allow Ca2+ influx via GPCR.
This slows down pacemaker conduction (slower upstroke) and decreases myocyte contractility (Phase 2)
Classify and describe the mechanism of action of Adenosine.
Miscellaneous
Binds Adenosine Receptor 1 of pacemaker cell to inhibit Ca2+ influx and stimulate K+efflux. –> Slows conduction –> slows HR
Classify and describe the mechanism of action of Digoxin.
Miscellaneous
Mimics the vagal nerve to decrease HR (phase 4) and AV node conduction (phase 0).
Also blocks Na/K plus channel leading to more intracellular ca2+ –> increased contractility.
Contraindications/Toxicities of Class 1c Drugs?
Contraindicated in patients with coronary artery disease (CAD), history of myocardial infarct (MI), or signs of heart failure (HF)