Pharmacology Flashcards
1
Q
what is the maximum rate of IV potassium infusion that can be conducted without monitoring
A
10mmol/hr
2
Q
what TB treatment causes peripheral neuropathy
A
Isoniazid
3
Q
where is the primary site of metabolism for opioids
A
liver - many enzyme systems particularly the CYP450 system
4
Q
what are the two phases of opioid metabolism
A
phase I: oxidation, reduction and hydrolysis
phase II: conjugation reactions like glucuronidation - morphine is glucuronidated into morphine-3-glucuronide (inactive) and morphine-6-glucuronide (active and potent)
5
Q
how are most opioids excreted
A
via the kidneys - renal impairment can lead to accumulation of metabolites and increase toxicity risk
6
Q
A
