Pharmacology

Question 1

examples of NSAIDs

Question 2

main usage of NSAIDs

Answer 2

anti-inflammatory
- inhibits enzyme involved in production of inflammatory mediators

analgesics
- inhibits the prostaglandin E2 receptor on nociceptor

antipyretic
- reduces fever

Question 3

moelcular target of NSAIDs (general information)

Answer 3

inhibits prostaglandin H2 synthase/Cycloxygenase enzyme

involved in conversion of phospholipid into prostanoids

Question 4

prostaglandin synthesis definition

Answer 4

biological pathway for conversion of phospholipids into prostanoids

Question 5

arachidonic acid synthesis definition

Answer 5

membrane phospholid cleaved by phospholipase A2 to produce artachidonic acid

Question 6

chemical structure of phospholids and PLA2 mechanism of action

Question 7

cytosol PLA2 domain structural features

Question 8

catalytic mechanism of hydrolysis reaction of phospholids to serine with R2 phospholid and lyso phospholid

Question 9

process of release of arachidonic acid from serine