Pharmacology Flashcards
Which chemotherapeutic agent has been associated with cardio toxicity?
Doxorubicin
Which chemotherapeutic agent has been associated with cystitis?
Cyclophosphamide
Which chemotherapeutic agent has been associated with anaphylaxis?
L-asparaginase
Which chemotherapeutic agent can cause pancreatitis?
Lomustine
Aminoglycosides are known for their potential toxic effects to what organ?
Kidneys
Penicillins and Cephalosporins fall under what class of antimicrobials drugs?
Beta Lactams
What is the mechanism of action of penicillins and cephalosporins?
Inhibits formation of petidoglycan cross-links of bacterial cell wall.
What is the spectrum of activity of penicillins and cephalosporins?
Gram-Positive limited Gram-Negative Anaerobes
Are penecillins and cephalosporins cidal or static?
Cidal
Are penicillins and cephalosporins time or concentration dependent?
Time
Beta lactamase inhibitors can be used to extend what?
The anti-bacterial spectrum
Gentamicin and Amikacin fall under what class of antimicrobials drugs?
Aminoglycosides
What is the mechanism of action of aminoglycosides?
Interfere with protein synthesis
What is the spectrum of activity of aminoglycosides?
Limited Gram-Positive Gram-Negative
Are aminoglycosides time or concentration dependent?
Concentration