Pharmacology Flashcards

1
Q

exceptions to SNS PSNS NT rules

A

1) SNS activates sweat glands with ACh via mAChR—>Sweat
2) SNS activates adrenal medulla with ACh via nAChR—>EPI/NE release

Renal smooth muscle responds to DA release from SNS

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2
Q

nAChR

A

ionotropic (ligand gated ion channels0
in the brain and adrenal medulla
excitation
agonists: ACh, Nicotine

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3
Q

mAChR

A

metabotropic (GPCR)
PSNS: CNS, autonomic ganglia, effector organs: cardiac, smooth muscles, glands, nerve terminals), and sweat glands (SNS)

Excitatory or inhibitory, agonized by ACh and muscarine

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4
Q

M2 receptors

A

PSNS receptor on the heart
Inhibits cAMP—>inc K conductance—>
decrease HR

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5
Q

M3 receptor

A

PSNS receptor found on glands, smooth muscle, endothelium

IP3/DAG—>muscle contraction in lung smooth muscles

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6
Q

Tyr—>DOPA–>DA

A

within the nerve cytoplasm

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7
Q

DA—>NE—>EPi

A

occurs within the vesciles of teh neurons

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8
Q

VMAT-2

A

shuttles in NTs into vesicles
-promiscuous (NE, Ei, DA, 5HT)

release upon after Ca2+ influx

if this is blocked by RESERPINE—>decreased SNS tone–>decrease BP

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9
Q

NET and DAT

A

NE and DA transporters that bring these NTs back into neuron where they can be recycled by MAO and COMT

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10
Q

A1 adrenergic receptors

A

found postsynaptically in smooth muscle
Epi> NE

cause contraction of ALL smooth muscle
ex: vasoconstriction
blocked pharmacologically for HT

NO PSNS ON VASCULATURE

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11
Q

B2 adrenergic receptors

A

found mostly in smooth muscle

EPI»NE

think epi pin

Cause smooth muscle relaxation
ex: vasodilation (lungs)

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12
Q

B1

A

found in cardiac muscle

Epi=NE

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13
Q

A2

A

found mostly pre junctional

Epi>NE

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14
Q

Muscarinic receptors on the heart

A

contract smooth muscles

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15
Q

Innervation of the vasculature

A

A1—>vasoconstriction (SNS)
NO PSNS receptors….but muscarinic agonists give IV cause VD due to activation or endothelial release of NO
*think nitroglycerine (causes relaxation of cardiac vessels by this mechanism-do not give exo ACh)

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