Pharmacology

Question 1

What channels do class 1A drugs block

Answer 1

Moderate block of Na+ channels

Question 2

What is the action of class 1A drugs

Answer 2

Prolong AP duration and the refractory period (slow down conduction velocity)

Question 3

What channels do class 1B block

Answer 3

Weak block of Na+ channels

Question 4

What is the action of class 1B drugs

Answer 4

Shorten AP duration and prevent premature beats

Question 5

What channels do class 1C drugs block

Answer 5

Strong block of Na+ channels

Question 6

What is the action of class 1C drugs

Answer 6

Depress conduction and prolong QRS

Question 7

What channels do class 2 drugs block

Answer 7

B adrendoceptors

Question 8

What is the action of class 2 drugs

Answer 8

Decrease the rate of depolarisation in the SAN and AVN

Question 9

What channels do class 3 drugs block

Answer 9

K+ channels

Question 10

What is the action of class 3 drugs

Answer 10

Prolong AP duration increasing the refractory period

Question 11

What channels do class 4 drugs block

Answer 11

Ca2+ channels

Question 12

What is the action of class 4 drugs (2)

Answer 12

Slow conduction in the SAN and AVN , decrease the force of contraction

Question 13

State 4 class 1 drugs

Answer 13

• lignocaine
• quinidine
• flecanide
• propafenone

Question 14

Give an example of a class 2 drug

Answer 14

Propanolol

Question 15

State 3 class 3 drugs

Answer 15

• amiodarone
• sotalol
• dronedarone

Question 16

Give an example of a class 4 drug

Answer 16

Verapamil

Question 17

Give an example of an ACE inhibitor

Answer 17

Ramipril, lisinopril