Pharmacology Flashcards
What’s MOA for ACyclovir
✓Inhibits herpes virus DNA polymerase competitively
✓incorporated in viral DNA and stops lengthening of DNA strand
………. Used to prevent and treat Cytomegalovirus (CMV) diseases.
Cidofovir
Does not require activation by viral (or cellular) kinases.
Foscarnet
Used in Acyclovir-‐resistant HSV and herpes zoster infections.
Foscarnet
Inhibits influenza virus Neuraminidase enzyme
Oseltamivir (Tamiflu®)
Zanamivir
First line drug for chronic hepatitis B
Lamivudine
inhibitor of both (HBV) DNA polymerase and
(HIV) reverse transcriptase
Lamivudine
(Flu-‐like syndrome ) side effect for which drug
Interferons alpha
Is not active orally
Interferons
What is the active form ( phosphorylated ) of lamivudine ?
Nucleoside revers transcriptase inhibitors( NRTI)
Used to Management of respiratory syncytial virus
Ribavirin
Adjunct to alpha interferons to treat HCV
Ribavirin
Is a nucleotide analog that prevents replication of HBV.
Adefovir
HIV protease inhibitors
Lopinavir
Ritonavir
Lopinavir and Ritonavir are….
Reversible inhibitors of the HIV aspartyl protease
Lopinavir
Ritonavir
Raltegravir is
HIV integrase inhibitor
What is the side effect of raltegravir
Myopathy
It is Entry inhibitor drug that Binds to HIV-‐1 envelope transmembrane glycoprotein(gp41)
Enfuviritide
It is Entry inhibitordrug that Targets the host cell chemokine co- receptor (CCR5) and block the attchment
Maraviroc
Polymerase inhibitors
Acyclovir
Cidofovir
is the only agent that prevents relapses of the
Primaquine
Effective agent for prophylaxis from all plasmodia
Mefloquin
Used with artemisinin to treat multidrug resistant forms of P. Falciparum
Mefloquin
