Pharmacology

Question 1

Abortive Tx for seizures

Answer 1

Benzodiazepines and barbiturates

Question 2

Indicated for trigeminal neuralgia

Answer 2

Carbamazepine

Question 3

Mechanism of benzodiazepines

Answer 3

Increase frequency at which chloride ions are open

Question 4

Mechanism for barbiturate

Answer 4

Increase duration at which chloride ions are open

Question 5

Steve Johnson’s syndrome

Answer 5

Harsh rash caused by ethosuxemide , carbamazepine and lamotrigine can lead to a toxic epidermal necrolysis

Question 6

Mechanism of valproate

Answer 6

Decrease voltage gated sodium and increase GABA

First line for generalized T-C

Question 7

Side effects of valproate

Answer 7

Anaemia, liver hepatotoxicity, pancreatitis, spina bifida

Question 8

Mechanism of phenytoin

Answer 8

Decrease V gated Na channels
More so for focal seizures

Question 9

Side effects from phenytoin

Answer 9

Gingival hyperplasia, Fetal hydration syndrome, zero kinetic and P450 inducer

Question 10

Mechanism of ethosuximide

Answer 10

Decrease T type calcium

Question 11

Indication for ethosuximide

Answer 11

Absence seizure

Question 12

Mechanism of carbamazepine

Answer 12

Increase refractory period of V gated Na channels

Question 13

Mechanism for lamotrigine

Answer 13

Decrease glutamate and decrease V gated Na channel

Question 14

Mechanism of Levetiracetam

Answer 14

Unknown

Question 15

Tiagabine and Vigabatrim

Answer 15

Increase GABA

Question 16

Topiramate

Answer 16

Decrease V gated Na channels