Pharmacology

Question 1

Bioavailability

Answer 1

Bioavailability= AUC (route of admin) / AUC (IV)

AUC= Area under concentration/ time curve

Question 2

Elimination- Wash Out Curve

Answer 2

C= C₀*e^-kt

C= Concentration

C0= Concentration at time 0

e= Euler’s number= 2.718

k= Rate Constant

t= time

Question 3

Enzyme/ Drug Reaction

Answer 3

KD= [D][R]/[DR]

affinity = 1/KD

KD= Dissociation constant

D= Free drug

R= Receptor

DR= Drug Occupied Receptor

Question 4

Enzyme Kinetics

Answer 4

Vi= Vmax [S]/ Km + [S]

Vi= Initial Velocity

Vmax= Max Initial Velocity

Km= Conc. at which the initial velocity is half the max initial velocity

S= Substrate

Question 5

Volume of Distribution

Answer 5

Vd= D/ C0

Vd= Volume of Distribution

D= Dose

C0= plasma conc. at time 0

Question 6

Time Constant

Answer 6

T= 1/ K

T= Vd/Cl

T= Time constant

K= rate constant

Vd= Volume of Distribution

Cl= Clearance

Question 7

Half-Life

Answer 7

t(½)= Tlog(e)2

t(½)= Half-Life

T= Time constant

Question 8

Loading Dose

Answer 8

Loading Dose=Vd*Cp

Vd= Volume of Distribution

Cp= Target Plasma Concentation

Question 9

Maintenance Dose

Answer 9

Maintenance Dose= Cp * Cl

Cl= Clearance

Cp= Plasma Conc.

Question 10

Three Compartment Model Clearance

Answer 10

Cp= (Ae^-at) + (Be^-Bt) + (Ge^-yt)

A= Central Compartment

B= Rapid Compartment

G= Slow Compartment/ Terminal Elimination Phase