Pharmacology

Question 1

MOA Statins

Answer 1

HMG-CoA Reductase inhibitor. Ultimately lowers LDL production in the liver (and increases clearance of LDL)

Question 2

Which anes drugs are dosed based on total body weight? Ideal? Lean?

Answer 2

Total: Sux, maintenance propofol gtt
Ideal: NDMBs
Lean: Everything else (including induction propofol)

Question 3

Cocaine MOA

Answer 3

prevents the presynaptic reuptake of catecholamines, primarily NE (causing alpha agonism)

Question 4

Drugs cleared by PLASMA esterases

Answer 4

Remifentanil, Chlorprocaine, Succinylcholine

Question 5

Succinylcholine action is stopped by

Answer 5

Redistribution into plasma (pseudocholinesterase/butylcholinesterase/plasma cholinesterase acts there)

Question 6

MOA Clopidogrel

Answer 6

inhibits ADP binding to P2Y12 receptor which would ultimately activate GPIIb/IIIa receptor that causes platelet aggregation

Question 7

What is DDAVP?

Answer 7

Analog of ADH. Low vasopressor activity. High anti-diuretic activity. Releases endothelial stores of factor 8:vWF and Factor 8:c

Question 8

What is fenoldopam?

Answer 8

Dopamine (D1) partial agonist
Increases urine production
SFx: Can cause dramatic hypotension

Question 9

Amiodarone MOA

Answer 9

K and Ca channel blockers
slows conduction and refractory period of the SA and AV nodes. Also prolongs refractory periods of ventricles, bundles of His, and Purkinje fibres.

Question 10

Adenosine location of action

Answer 10

AV node

Question 11

How do you treat extra pyramidal symptoms caused by reglan/zofran/etc.

Answer 11

Benadryl or benztropine