Pharmacology Flashcards
Name a H2 receptor antagonist used to treat peptic ulcer disease!
Ranitidine
Parietal cell histamine receptors are blocked which decreases HCl secretion
Name a proton pump inhibitor!
Omeprazole
Which drug may reduce the effects of long-term NSAID treatment?
Misoprostolol (PGE1 analogue)
What side effects can a NSAID have on the GI tract?
Gastric bleeding
Mucosal ulceration
Why do NSAIDs cause gastric ulceration and bleeding?
Inhibit COX enzyme and thus block PGE formation - PGE reduces gastric acid secretions
What are the 3 main aims of drug treatment for peptic ulcers?
Decrease gastric secretions
Increase mucosal resistance
Eradicate H. pylori
What do proton pump inhibitors block?
The proton pump on the apical membrane (NOT the ones in tubulovesicles)
Name two mucosal strengtheners!
Sucralfate
Bismuth chealate
Name 2 anti-emetic agents that are antagonists of the 5-HT3 (serotinin) receptor!
Ondansetron
Palonosetron
Ondansetron (5-HT3 antagonist) is effective in reducing vomiting in chemotherapy patients, but has no effect on motion sickness.
True/ False?
True
Name an NK1 antagonist used in conjunction with 5-HT3 antagonist in highly emetogenic chemotherapy!
Aprepitant
Name a muscarinic ACh antagonist that can be used to treat motion sickness!
Hyosine
Scopolamine
Name a H1 antagonist that can be used to treat motion sickness + nausea/vomiting caused by irritants!
Cyclizine
Name a dopamine antagonist used for drug-induced and GI disease -induced vomiting!
Metoclopramide
