Pharmacology Flashcards
1
Q
How does volume of distribution compare in preterm vs term?
A
Preterm have larger volume of distribution compared to term
2
Q
What do acidic drugs usually bind in serum? Basic drugs?
A
Acidic = bind albumin Basic = bind alpha glycoproteins and lipoproteins
3
Q
What is a phase I reaction?
A
Metabolism of drug via oxidation, reduction, hydrolysis, demethylation
75% of drugs modified this way
4
Q
What are examples of medications metabolized by cytochrome p450?
A
Phenobarbital, theophylline, caffeine, phenytoin
5
Q
What is zero order kinetics?
A
Linear line of drug concentration
Examples: aspirin, chloramphenicol, ethanol, diazepam
