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Psychiatric pharmacology > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

Mechanism of action for alcohol withdrawal?

A

Decreased inhibition of GABA and increased NMDA glutamate transmission

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2
Q

Acamprosate for alcohol withdrawal?

A

Neuroprotective increasing the effect of GABA-A

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3
Q

Naltrexone for alcohol withdrawal?

A

Blocks opioid pathway for alcohol so decreases the positive reward

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4
Q

Disulfiram for alcohol withdrawal?

A

Prevents acetaldehyde breakdown, however unwanted SE such as flushing, N, increased BP, increased temp and pulse

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5
Q

Tricyclic antidepressants MoA?

A

Block 5-HT and NA transporters

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6
Q

Tricyclic antidepressants SE?

A

Can’t see, wee, spit, shit

Overdose invokes seizures

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7
Q

Tricyclic antidepressants examples?

A

Imipramine, amitriptyline, clomipramine

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8
Q

SSRI SE?

A

GI symptoms (N/D)
Headache
Increased bleed risk
Agitation, anesthesia, anxiety

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9
Q

Citalopram specific SE?

A

Increased risk of QT prolongation

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10
Q

Paroxetine (SSRI) and pregnancy?

A

Increase risk of congenital malformation

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11
Q

SSRI examples?

A

Citalopram, fluoxetine, sertraline, citalopram, paroxetine

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12
Q

SSRI use and MoA?

A

1st line for depression

Inhibit Serotonin reuptake

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13
Q

SSRI CI?

A

NSAIDs, warfarin/heparin, triptans

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14
Q

Examples of antipsychotics?

A

Risperidone, haloperidol, olanzapine, quetiapine, clorazapine

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15
Q

Antipsychotics MoA?

A

Work by inhibiting DA neurotransmission (antagonist)

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16
Q

SE of antipsychotics?

A

Motor - acute dystonia, akathisia, tardive dyskinesia

DM, increased weight, dysglycaemia, dyslipidaemia

17
Q

Neuroleptic malignant syndrome treatment?

A

DA agonist

18
Q

Neuroleptic malignant syndrome (NMS) symptoms?

A

Tremor, muscle cramps, fever, delirium, autonomic instability

19
Q

What is the SSRI of choice in children and adolescents?

A

Fluoxetine

20
Q

What is the most effective atypical antipsychotic for schizophrenia - why should it be monitored?

A

Clozapine

Fatal agranulocytosis (decreased number of WBC in the blood)

21
Q

What medication is used for severe cases of PTSD?

A

Risperidone

22
Q

What are the management options for PTSD?

A

Trauma focused CBT

Venlafaxine or Sertraline (SSRI)

23
Q

What is the mechanism of action of venlafaxine?

A

Serotonin-noradrenaline reuptake inhibitor

24
Q

Most MI what is the drug of choice for a depressed patient?

A

Sertraline

Psychiatric pharmacology (2 decks)

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