Pharmacologie

Question 1

Quelles sont les classes d’anti-arrythmiques ?

Answer 1

Class I : Sodium channel blockers
Class II : Beta-blockers
Class III : Potassium channel blockers
Class IV : Calcium channel blockers
Class V : Others

Question 2

MOA Diltiazem

Answer 2

Class IV : Calcium channel blockers

Question 3

MOA Sotalol

Answer 3

Class II : Beta-blocker surtout
Potassium channel blockers (arythmies supraV et ventriculaires car joue sur la repolarisation des cellules)

Question 4

MOA mexilitine

Answer 4

Class Ib : Sodium channel blockers

Question 5

MOA Atenolol

Answer 5

Class II: Beta-blocker –>Sélectif B1(minimal B2 effet at high doses)

Question 6

MOA lidocaine

Answer 6

Class Ib : Sodium channel blockers

Question 7

MOA Digoxin

Answer 7

Class V : Na+/K+ ATPase

Question 8

MOA Procainamide

Answer 8

Classe Ia : Sodium channel blockers
Potassium channel blocker

Question 9

MOA Propafenone

Answer 9

Class Ic : Sodium channel blockers
Potassium channel blocker

Question 10

MOA Amiodarone

Answer 10

Class III : Potassium channel blockers
Beta-blocker
Sodium channel blockers
Calcium channel blockers

Question 11

Lieu d’action sur le rein des diurétiques : Furosemide

Answer 11

Loop of Henle : Inihibiteur deu co-transporteur Na+/K+/2Cl- ATPase

Question 12

Lieu d’action sur le rein des diurétiques : Spironolactone

Answer 12

Inhibiteur des récepteurs à l’aldostérone et Potassium sparing diuretic
Tubules contournés distaux ou tubule collecteur selon les sources

Question 13

Lieu d’action sur le rein des diurétiques : Hydrochlorothiazide

Answer 13

Tubules collecteurs
Bloque les transporteurs Na+/Cl-

Question 14

MOA Atenolol

Answer 14

Beta-blocker (B1 selective). À haute dose peut être légèrement B2
Inotrope -, chronotrope -
(Diminue sinus HR & AV conduction + Diminue O2 myocardial consumption)

Question 15

MOA Clopidogrel

Answer 15

Binds to platelet surface ADP ( P2Y12) & irreversibly alters receptor for the lifespan of the platelet

Question 16

MOA Rivaroxaban

Answer 16

Inhibitor of activated clotting factor Xa & prothrombinase activity

Question 17

MOA Heparin

Answer 17

Binds to anti-thrombin & change conformation which accelerates the binding of anti-thrombin to activated clotting factor (Xa, IIa ++) to inactivate their procoagulation activity
Inhibits factor XIII

Question 18

MOA TPA

Answer 18

Tissue plasminogen activator : thrombolysis

Question 19

MOA Warfarin

Answer 19

Inhibits Vitamin K epoxidase reductase (VKOR1) which interferes with Vit K action in synthesis of clotting factors (II, VII,IX, X)
Anticoagulant of protein C & S

Question 20

MOA Pimobendane

Answer 20

Inhibitor of PDE III by increasing intracellular Ca2+ sensitivity in cardiac contractile apparatus. it increases AMPc in the cells.

Question 21

MOA Sildenafil

Answer 21

Inhibition of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type V found in smooth muscle of pulmonary vasculature (Increased GMPc)

Question 22

MOA Benazepril

Answer 22

Inhibitor of angiotensin converting enzyme (inhibits conversion of Ang I to II

Question 23

MOA Amlodipine

Answer 23

Dihydropyridine L-type calcium channel blocker that inhibits voltage gated Ca2+ channel in heart & vasculature smooth muscles

L-type calcium channel also found in afferent arteriole in kidney

Question 24

MOA Telmisartan

Answer 24

Selective blockage of AT1 receptor & aldosterone synthesis/secretion
leading to vasodilation & increased Na+ excretion