Pharmacological

Question 1

First generation antipsychotics

Answer 1

Haloperidol, Chlorpromazine

Question 2

First generation antipsychotics mechanism of action

Answer 2

Block dopamine (D2) receptors in brain

Question 3

Main Haloperidol side effect

Answer 3

EPSEs (dystonia, akasthesia, parkinsonism, tremor, tardive dyskinesia, oculogyric crisis),

Question 4

Antidote for EPSEs

Answer 4

Benztropine (anticholinergic, doesn’t work for Tardive Dyskinesia)

Question 5

Neuroleptic Malignant Syndrome- first or second generation pyschotics higher risk?

Answer 5

First generation, specifically Haloperidol but any dopamine receptor blocker

Question 6

Symptoms of neuroleptic malignant syndrome

Answer 6

Fever, rigidity, tremor, autonomic instability, raised CK. Can give bromocriptine.