Pharmacokinetics of Elimination (not complete) Flashcards
1
Q
Explain the derivation and clinical relevance of bioavailability (F)
A
a
2
Q
Explain the derivation and clinical relevance of volume of distribution (Vd)
A
a
3
Q
Explain the derivation and clinical relevance of clearance (Cl)
A
a
4
Q
Explain the derivation and clinical relevance of half life (t1/2)
A
a
5
Q
Explain the derivation and clinical relevance of the elimination rate constant (ke)
A
a
6
Q
Explain the derivation and clinical relevance of first-order kinetics
A
a
7
Q
Explain the derivation and clinical relevance of zero-order kinetics
A
a
8
Q
Describe first-order elimination
A
a
9
Q
Describe zero-order elimination
A
a
10
Q
How long does it take to reach a steady-state concentration?
A
For infusions or multiple oral doses —> 4-5 half-lives
