Pharmacokinetics Models Flashcards
Explain pharmacokinetics models
What is the purpose of pharmacokinetics
Explain the concept of compartment models
List the assumptions of compartment models
Homogenous distribution within compartments
Linear kinetics
Instantaneous distribution in central compartment
Constant physiological parameters
Negligible inter-compartmental delay
Explain the homogenous distribution within compartments assumption
Explain linear kinetics as an assumption
Explain instantaneous distribution in central compartment as an assumption
Explain constant physiological parameters as an assumption
Explain negligible inter-compartmental delay as an assumption
What are the advantages of compartmental model
What is the limitation of compartmental model
What are the types of compartmental models
Mamillary model
Catenary model
Explain mammillary model
Consists of one or more peripheral compartments connected to the central
They are joined parallel to the central compartment
The central compartment comprises of plasma and highly perfused tissues such as liver, lungs, kidneys, which rapidly equilibrate with drugs
Explain catenary model
Explain physiological model
In physiological model the drug concentration profile results from what
In physiological model the distribution of the drug depends on what
In physiological model the elimination capacity of the drug depends on what
Depends on the drug and the organ involved
The overall drug concentration profile results from what
Explain non compartment model
What equation is used in non compartment model
Define MRT
