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NGR6462 Pharm & Chem Anesthesia I > Pharmacokinetics/dynamics > Flashcards

Pharmacokinetics/dynamics Flashcards

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1
Q

small hydrophobic molecules diffuse across plasma membranes

A

Co2, O2

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2
Q

specific protein that is the site of binding

A

receptor

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3
Q

a compound that is specific for reach receptor and activates it

A

ligand

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4
Q

molecules neutral in charge

A

non-polar

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5
Q

molecule with partial negative and positive charge

A

polar

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6
Q

strongest bond strength

A

covalent

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7
Q

weakest bond strength

A

van der waals

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8
Q

receptor most prevalent in the body

A

G-protein

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9
Q

name the four receptor types

A

ion channel, g-protein, intrinsic enzyme, intracellular

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10
Q

ligand-gated ion channel examples

A

nicotinic, glutamate, GABA-A, glycine

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11
Q

play an important role in muscle contraction and propagation of action potential

A

voltage-gated

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12
Q

contains the alpha, beta, and gamma subunits

A

g-protein

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13
Q

second messenger actions are

A

tissue specific

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14
Q

long term treatment with agonist leads to

A

desensetization

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15
Q

long term treatment with antagonist leads to

A

hypersensitization

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16
Q

located in the CNS and peripheral tissues, and responsible for fight or flight response

A

adrenergic receptors

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17
Q

located in vascular smooth muscle and post-synaptic CNS

A

alpha 1

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18
Q

both pre and post synaptic, in pancreatic islet cells, platelets, and nerve terminals

A

alpha 2

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19
Q

post synaptic activation of alpha 2 receptors leads to

A

vasoconstriction and platelet aggregation

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20
Q

pre synaptic alpha 2 receptors

A

inhibit norepi release

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21
Q

activation of this receptor increases cAMP

A

beta

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22
Q

increases cAMP leading to vasodilation

A

D1, D5

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23
Q

decreases cAMP leading to vasoconstriction

A

D2, D3, D4

24
Q

two main cholinergic receptors

A

nicontinic and muscarinic

25
Q

ligand gated cholinergic receptor

A

nicontinic

26
Q

g protein coupled cholinergic receptor

A

muscarinic

27
Q

Nm found

A

post-synaptic skeletal neuromuscular

28
Q

Nn found

A

autonomic ganglia postganglonic

29
Q

acetylcholine opens sodiuma and potassium ion channels

A

cholinergic

30
Q

M2 located

A

cns, heart, smooth muscle, autonomic nerve terminals

31
Q

Gaba a receptor family

A

ligand gated

32
Q

gaba a ion

A

chloride

33
Q

gaba a located in

A

CNS

34
Q

gaba b located in

A

peripheral tissues

35
Q

gaba b receptor family

A

g protein

36
Q

both gaba receptor subtypes cause inhibition

A

post-synaptically

37
Q

gaba a meds

A

benzos, barbs

38
Q

gaba b meds

A

baclofen

39
Q

gaba chloride activation leads to

A

CNS depression

40
Q

all serotonin receptors are g-protein receptors except

A

5HT3- ligand gated

41
Q

serotonin ions

A

sodium and potassium

42
Q

zofran receptor family

A

serononin

43
Q

which histamine receptors are clinically pertinent

A

h1 h2

44
Q

histamine receptor family

A

g protein

45
Q

h1 location

A

CNS

46
Q

cause hives, bronchoconstriction, vasodilation

A

h1

47
Q

located in parietal cells of the stomach

A

h2

48
Q

regulates acid production

A

h2

49
Q

causes muscle relaxation

A

h2

50
Q

vasopressin receptor family

A

g protein

51
Q

causes vasodilation in pulmonary circulation

A

v1

52
Q

increase in calcium leads to vasoconstriction

A

v1

53
Q

v2 MOA

A

increase cAMP leads to water reabsorption, causes regulation of plasma volume, inducing the release of von-willebrand factor and factor vii

54
Q

found in the pituitary gland, involved in acth release and body temperature regulation

A

v3

55
Q

activation leads to dysphoria

A

kappa

56
Q

cyp2d6 rapid metabolizers experience

A

high morphine levels and toxicity

57
Q

most abundant cytochrome

A

3a4

NGR6462 Pharm & Chem Anesthesia I (4 decks)

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