pharmacokinetics as the basis of medication actions

Question 1

describe absorption

Answer 1

Passage of medication molecules into the blood from the site of administration

Question 2

what factors influence absorption

Answer 2

• Route of administration
• Ability of a medication to dissolve
• Blood flow to the site of administration
• Body surface area
• Lipid solubility

Question 3

describe distribution

Answer 3

 Circulation
 Membrane permeability
 Protein binding

Question 4

describe metabolism

Answer 4

Medications are metabolized into a less-potent or inactive form

Question 5

during metabolism what process occurs

Answer 5

biotransformation

Question 6

what influences biotransformation to happen during metabolism

Answer 6

enzymes that detoxify, break down, and remove active chemicals

Question 7

where does metabolism occur in the body

Answer 7

primarily in the liver

Question 8

what other organs in the body may be involved during metabolism

Answer 8

GI tract, the lungs, and the kidneys.

Question 9

describe excretion

Answer 9

Medications exit the body

Question 10

where does excretion (medications exit the body) takes place in the body

Answer 10

primarily takes place in the kidneys via urine

Question 11

what are the other routes of where excretion can take place

Answer 11

saliva
sweat
tears
feces

Question 12

what parts of the body are involved in excretion

Answer 12

Kidney
* Liver
* Bowel
* Lungs
* Exocrine glands

Question 13

what does the chemical make up of medication determine

Answer 13

the organ of excretion