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Hypertension Exam Yr1 > Pharmacokinetics and stability > Flashcards

Pharmacokinetics and stability Flashcards

1
Q

What are the three most common types of chemical degradation?

A

1) Hydrolysis
2) Oxidation
3) Photolysis

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2
Q

Henderson hasselbalch acid

A

pH = pKa + log [A-]/[HA]

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3
Q

Henderson hasselbalch base

A

pH = pKa - log [NH4+]/[NH3]

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4
Q

Log p

A

LogP = Log [oil]/[water]

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5
Q

LogD

A

LogD = [unionised in oil]/[unionised in water + ionised in water]

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6
Q

Clearance

A

Clearance = rate of elimination/concentration of plasma

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7
Q

Ln conc/time graph

A

LnCt = -KelimT + LnC0

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8
Q

Kelim

A

Gradient

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Hypertension Exam Yr1 (10 decks)

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