Pharmacokinetics Flashcards
Which HLA is associated with flucloxacillin associated liver failure?
HLA-B*5701
What is the equation for elimination?
clearance/volume of distribution
What is the equation for clearance?
dose/AUC
What is the equation for a half life?
(0.693 x volume of distribution)/clearance
What is a phase I reaction?
where a drug is altered in some way to make it more water soluble and less toxic e.g. oxidation, reduction or hydrolysis
What is a phase II reaction?
where the drug is coupled with another molecule to make it less active and more water soluble e.g. acetylation, glucuronidation, methylation
How many half lives does it take to clear a drug?
5
What is first order kinetics?
for every half life that passes the drug concentration is halved
What is zero order kinetics?
a constant amount of drug is eliminated per unit of time independent of how much drug is in the body