Pharmacokinetics Flashcards

1
Q

Which HLA is associated with flucloxacillin associated liver failure?

A

HLA-B*5701

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2
Q

What is the equation for elimination?

A

clearance/volume of distribution

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3
Q

What is the equation for clearance?

A

dose/AUC

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4
Q

What is the equation for a half life?

A

(0.693 x volume of distribution)/clearance

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5
Q

What is a phase I reaction?

A

where a drug is altered in some way to make it more water soluble and less toxic e.g. oxidation, reduction or hydrolysis

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6
Q

What is a phase II reaction?

A

where the drug is coupled with another molecule to make it less active and more water soluble e.g. acetylation, glucuronidation, methylation

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7
Q

How many half lives does it take to clear a drug?

A

5

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8
Q

What is first order kinetics?

A

for every half life that passes the drug concentration is halved

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9
Q

What is zero order kinetics?

A

a constant amount of drug is eliminated per unit of time independent of how much drug is in the body

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