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Infectious Disease > Pharmacokinetics > Flashcards

Pharmacokinetics Flashcards

1
Q

Peak target and trough levels for gentamicin in infective endocarditis

Dosing frequency?

A

Peak target: 3-4 mcg/mL
Trough: < 1 mcg/mL

Extended interval dosing not used

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2
Q

Azole effect on CYP450?

A

Potent inhibitor

All 3A4

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3
Q

Azoles are hepatically eliminated except which azole?

A

Fluconazole

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4
Q

Which azoles are pH-dependent?

A

Itraconazole
Ketoconazole
Space PPIs and H2RA by 2 hours

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5
Q

These medications can decrease posaconazole suspension absorption.

A

Cimetidine

PPIs

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6
Q

What type of kinetics does voriconazole display?

A

1st order then zero order

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Infectious Disease (14 decks)

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