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PHARM > Pharmacokinetics > Flashcards

Pharmacokinetics Flashcards

1
Q

Metoclopramide

A

Absorption: Enhances gastric emptying rate

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2
Q

Antacids

A

Absorption: affects absorption of drugs requiring gastric fluid acidity for dissolution, forms unabsorbable complexes with drugs in gastrointestinal tract

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3
Q

Proton pump inhibitors

A

Absorption: affects absorption of drugs requiring gastric fluid acidity for dissolution

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4
Q

Cholestyramine

A

Absorption: adsorbs drugs in gastrointestinal tract

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5
Q

Iron

A

Absorption: forms unabsorbable complexes with drugs in gastrointestinal tract

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6
Q

Thiopental

A

Distribution: anesthetic inducing agent, rapid distribution to brain (seconds)

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7
Q

Theophylline

A

Metabolism: substrate of CYP1A2

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8
Q

Warfarin

A

Metabolism: substrate of CYP2C9. Completely bound by plans plasma proteins and had GFR = 0

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9
Q

Cigarette smoke

A

Metabolism: inducer of CYP1A2

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10
Q

Carbamazepine

A

Metabolism: Inducer of CYPs 2C9, 2C19, 3A4

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11
Q

Phenobarbital

A

Metabolism: Inducer of CYPs 2C9, 2C19, 3A4

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12
Q

Phenytoin

A

Metabolism: Inducer of CYPs 2C9, 2C19, 3A4, example of saturable kinetics of elimination

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13
Q

Rifampin

A

Metabolism: Inducer of CYPs 2C9, 2C19, 3A4

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14
Q

St. John’s Wort

A

Metabolism: Inducer of CYPs 2C9, 2C19, 3A4

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15
Q

Ethanol

A

Metabolism: Inducer of CYP2E1

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16
Q

Azole antifungals

A

Metabolism: Inhibitors of CYP2C9 and CYP3A4

17
Q

Macrolide antibacterials

A

Metabolism: Inhibitors of CYP3A4

18
Q

HIV protease inhibitors

A

Metabolism: Inhibitors of CYP3A4

19
Q

Grapefruit juice

A

Metabolism: Inhibitors of CYP3A4 (intestinal form only)

20
Q

Cimetidine

A

Metabolism: broad spectrum inhibitor of many CYP450

21
Q

Ammonium chloride

A

Excretion: used to acidify urine and increase excretion of weak base drugs

22
Q

Sodium bicarbonate

A

Excretion: used to alkalinize urine and increase excretion of weak acid drugs

23
Q

Probenecid

A

Excretion: weak acid inhibitor of tubular secretion of weak acids by OATs

24
Q

Cimetidine

A

Excretion: weak base inhibitor of tubular secretion of weak bases by OCTs

25
Q

Penicillin

A

Excretion: weak acid drug eliminated primarily by renal tubular secretion

26
Q

Creatinine

A

Excretion: used to estimate GFR

27
Q

p-Aminohippuric acid

A

Excretion: used to estimate renal plasma flow

PHARM (6 decks)

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