Pharmacokinetics

Question 1

Pharmacogenetics vs Pharmacogenomics

Answer 1

Variable response due to individual gene(s)

Variable response due to multiple loci across the genome

Question 2

Kinetics vs Dynamics

Answer 2

Pharmacokinetics:
– Describes absorption, distribution, metabolism and excretion of drugs (ADME)
Pharmacodynamics:
– Describes the relationship between the concentration of a drug at its site of action and the observed biological effects.

Question 3

Phase I vs II

Answer 3

Phase I : polar group added (exposed)–> solubilize

Phase II : conjugation reaction (sugar/ acetyl group) –> detoxify

Question 4

CYP450

Answer 4

Most CYPs inactivate drugs (only some activate)

There’s WIDE genetic polymorphic variation with phenotypic consequences in the CYP families of
genes, which is why they are so important to prescribing physicians

Question 5

CYP2D6

Answer 5

Codeine (ACTIVATION!)
Tricyclic antidepressants
Inibited by: Quinidine, Fluoxetine, Paroxetine

Question 6

CYP2C9 + VKORC1

Answer 6

Warfarin

Question 7

NAT

Answer 7

Isoniazid

Question 8

TMPT

Answer 8

6-mercaptopurine/6- thiguanine and childhood ALL

Question 9

G6PD

Answer 9

sulfonamide, dapsone
X-Linked
hemolytic anemia after sulfa drugs or maybe dapsone

Question 10

CYP3A

Answer 10

Cyclosporine
Inhibitor: ketoconazole, grapefruit juice
Inducer: rifampin