Pharmacokinetics

Question 1

What are the factors that influence PK

Answer 1

Partition Coefficient
Drug solubility
Therapeutic window
Adverse drug reactions

Question 2

What is partition coefficient

Answer 2

Indicates how hydrophilic or hydrophobic a drug is
(drug must be able to do both)

Question 3

What is drug solubility?

Answer 3

Determines absorption and distribution parameters

Question 4

How is partition coefficient determined?

Answer 4

by a ratio of its fat solubility and its water solubility

Question 5

What is the solubility of a drug in plasma?

Answer 5

Hydrophilic as plasma is water and salts

Question 6

What does a drug need to be in order to cross a membrane?

Answer 6

Slightly lipophilic

Question 7

What is a therapeutic window?

Answer 7

Concentration range at which a drug is effective without causing undesirable physiological effects

Question 8

What are adverse drug reactions?

Answer 8

Undesirable side affects either dose related or individual variation