Pharmacokinetics Flashcards
Antagonists _________ receptor activity.
Block
Naloxone blocking opioid receptor
For drugs to achieve that critical concentration of drug in the body
Dosing schedules
For drugs that take a longer time to reach a concentration. Ex: take 2 pills the first day, then 1 pill a day after that.
Loading dose
The drug is dissolving from a solid form to a liquid form in the GI tract so it can be absorbed.
Pharmaceutic phase
ONLY oral meds go through this phase!
Does not dissolve until they reach the alkaline environment in the small intestine.
Long acting or Enteric coated tablets
Suffix for long-acting drugs
-EC, -ER, -SR, -XL
Enteric coated, extended release, slow release, extra long
Most antibiotics are NOT ______ soluble. Very hard to treat brain infections.
Lipid
What is Metabolism AKA?
Biotransformation
Where is most of Cytochrome P-450 found in most cells?
Liver
What drugs are known to induce/increase P-450 activity?
Alcohol, nicotine, and glucocorticoids.
Will not kill the bacteria as effectively because the alcohol will speed up the metabolism, thus preventing them from reaching the therapeutic levels.
What drug can inhibit/decrease P-450 activity?
Amiodarone
The breakdown of oral drugs in the liver immediately after absorption.
First-Pass Effect
Antibiotic dose is based on the patient’s ______ level.
Trough
What are Opioid side effects?
Constipation, headaches, drowsiness, nausea
When a person’s body makes antibodies to a drug or drug protein.
Allergic Reaction
