Pharmacokinetic Interactions Flashcards
Pharmacokinetic interaction refers to?
The fluctuation in bioavailability of herb/nutrient/drug substances in the body as the result of changes in absorption, distribution, metabolism and elimination.
The passage of herbs, nutrients and drugs from the outside to the inside of the body is referred to as?
Absorption
The majority of all absorption occurs in the?
Intestines
Botanicals may be adversely affected when they are given together with some drugs due to?
Binding in the G.I. Tract
Herbs may be adversely affected when the herbs are given together with some drugs that change what?
The PH of the stomach
Which 3 drugs are known to decrease absorption?
Questran
Colestid
Carafate
Which antacids may neutralize, decrease or inhibit the secretion of stomach acid? (5)
Tagamet Pepcid Axid Zantac Prilosec
What can a herbalist do to minimize the risk of interaction? (2)
- Herbs and drugs be taken separately by at least two hours
- by taking digestive enzymes with the botanical indicated
Drugs that affect the ___________ may affect the absorption of herbs.
G.I. Motility
What is G.I. Motility?
The rate at which the intestines contract to push the content form the stomach to the rectum.
Slower G.I. Motility means? (2)
- herbs stay in the intestines for a longer period of time
- there may be an increase in absorption
Faster G.I Motility means? (2)
- herbs stay in the intestines for a shorter period of time
- there may be a decrease in absorption
Decreased G.I. Motility may?
Increase absorption
Increased G.I. Motility may?
Decrease absorption
