Pharmacogenomics

Question 1

Butyrylcholinesterase (BChE)

Answer 1

Hydrolysis of short acting muscle relaxer Succinylcholine

Question 2

N-acetyltransferase 2 (NAT2)

Answer 2

Catalyzes the acetylation of Isoniazid, Hydralazine, Procainamide

Question 3

Slow acetylator phenotype

Answer 3

Drug toxicities

Question 4

Fast acetylator phenotype

Answer 4

Active drugs quickly metabolized and innactivated. Pro-drugs may result in overdose.

Question 5

Thiopurine S-Methyltransferase (TPMT)

Answer 5

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine and azathiopurine immunosuppressant agents

Question 6

TPMT*3A

Answer 6

Results in decrease in tissue levels of TPMT

Question 7

Homozygous for TPMT*3

Answer 7

At risk for life threatening myelosuppression when treated with standard doses of thiopurine drugs

Question 8

5-Lipoxygenase

Answer 8

target for asthma drug Zileuton

Question 9

Zileuton

Answer 9

decreases airway inflammation by inhibiting 5-lipoxygenase

Question 10

ALOX5

Answer 10

Gene that encodes for 5-lipoxygenase enzyme

Question 11

5 repeat ALOX5 allele

Answer 11

Express more 5-lipoxygenase

Question 12

S-Warfarin is metabolized primarily by?

Answer 12

CYP2C9

Question 13

Varient alleles of S-Warfarin

Answer 13

Associated with decreased levels of CYP2C9

Question 14

Warfarin’s target?

Answer 14

Vitamin K epoxide reductase

Question 15

This gene that encodes Vitamin K epoxide reductase has been found to have a haplotype associated with a low dose requirement?

Answer 15

Vitamin K epoxide reductase complex 1 (VKORC1)

Question 16

This has been reported to have an association with abacavir (a reverse-transcriptase inhibitor)?

Answer 16

HLA-B*5701