pharmacogenomics

Question 1

Gene

Answer 1

a series of nucleotides that CODE for a single protein

Question 2

Allele

Answer 2

specific form of a gene
Wild-type allele = more common

Variant = less common

Question 3

Genotype

Answer 3

unique genes that determine a specific tratit

Question 4

Phenotype

Answer 4

An observable trait of the genotype (“blue eyes”

Question 5

Single nucleoside polymorphism (SNP)

Answer 5

A change in a single nucleotide (C replaced with G)

Question 6

What drugs need HLA testing?

Answer 6

Abacavir (Epzicom, Triumeq)
Allopurinol (Zyloprim, Aloprim)
Carbamazepine (Tegretol)
Oxycarbamazepine (Trileptal)
Phenytoin (Dilantin)
Fosphenytoin (Cerebyx)

Question 7

What drug is a prodrug of CYP2C19?

Answer 7

Clopidogrel (Plavix)

Question 8

What drug is a prodrug of CYP2D6?

Answer 8

Codeine
**Do not use with ultrametabolizer

Question 9

What alleles may result in increased bleeding with warfarin use?

Answer 9

CYP2C9*2 or *3 or VKORC1

Question 10

What drug should you avoid if a patient is positive for KRAS mutation?

Answer 10

Cetuximab (Erbitux)
***EGFR inhibitor

Question 11

What drug should be avoided in DPD deficiency?

Answer 11

Capecitabine (Xeloda)
Fluorouracil