Pharmacogenetics Flashcards
1
Q
Drugs commonly prone to variations
A
- Warfarin
- Aspirin resistnance
- Clopidogrel
- Rosuvastatin
2
Q
CYP2D
A
3
Q
Warfarin genetics
A
- CYP2C9 polymorphism
- Variation in metabolism of S-enantiomer; reduced clearence, i.e. lower doses
- VKORC1 differences
- Pharmacodynamic, warfarin resistance
4
Q
Aspirin resistance
A
- 25% of patients
- Increased risk of CVD
5
Q
Genetics in clopidogrel
A
- Is a prodrug, activity influenced by genotype
- PQN1 Q192R polymorphisms; increased risk of thrombosis
6
Q
Example of apolymorphism in a drug target
A
beta2 adrenoceptors in asthma and a1 in CHF
7
Q
Rosuvastatin and racial groups
A
Max dose. 40mg caucasian
20mg asian
