Pharmacodynamics (PD): Drug targets

Question 1

define receptors?

Answer 1

proteins that are able to recognise a specific ligand

Question 2

what is an endogenous receptor

Answer 2

natural, inert to the body e.g neurotransmitter/hormone

Question 3

What is synthetic receptor?

Answer 3

which are not inert to the body, things which enter the body such as drugs, chemicals

Question 4

when making a drug, what are the important things to and define them

Answer 4

1. drug specificity - drugs should only act at the desired drug target, e.g a family of receptors, ach will ach will be able to act on all

2, Drug selectivity - even the best drugs only act selectively at the drug target and this can lead to unwanted drug effecrs if you increase the concentration

Question 5

name 3 g protein coupled receptors ?

Answer 5

adenosine receptor
dopamine receptor
cannabinoid receptor

Question 6

examples of what adenosine receptor acts on

Answer 6

caffeine, theophylline

Question 7

examples of what dopamine receptors act on

Answer 7

l-dopa, haloperidol

Question 8

examples of what cannabinoid receptors act on

Answer 8

cannabis, rimonabant, sativex