Pharmacodynamics and SAR

Question 1

<p>potency</p>

Answer 1

<p>relates the drug effect to drug dose</p>

Question 2

<p>efficacy</p>

Answer 2

<p>drug's maximum effect</p>

Question 3

<p>narrow therapeutic index drug</p>

Answer 3

<p>narrow dosing range over which patients do not experience toxicity - requires close therapeutic monitoring</p>

Question 4

<p>wide therapeutic index drug</p>

Answer 4

<p>wide dosing range over which patients do not experience toxicity</p>

Question 5

<p>therapeutic index</p>

Answer 5

<p>range between the effective dose and the toxic dose in patients</p>

Question 6

<p>clinical therapeutic index</p>

Answer 6

<p>TD50/ED50</p>

Question 7

<p>dosing range</p>

Answer 7

<p>range of doses in between dose that produces lowest measurable response and dose that produces max measurable response</p>

Question 8

<p>graded dose-response curve</p>

Answer 8

<p>measures response to a drug over a range of doses

| determine efficacy and potency</p>

Question 9

<p>quantal dose-response curve</p>

Answer 9

<p>measures frequency of a drug response over a range of drug doses in a population of subjects
determine dosing range</p>

Question 10

increase agonist concentration effect on competitive antagonist

Answer 10

decrease effect, reverse if large enough

Question 11

narrow Therapeutic range according to FDA

Answer 11

<3-4

Question 12

pharacophore

Answer 12

essential portion of a drug molecule required for causing an effect at the site of action