Pharmacodynamics Flashcards
Stimulating Action
direct effects from a receptor agonist that stimulates the body.
receptor
protein molecule in a cellular membrane that can bind to a complementary molecule
agonist
chemical capable of activating a receptor to generate a therapeutic response
partial agonist
only partially activates the receptor
Depressing Action
direct effects from a receptor agonist that depresses the body
Antagonizing Action
a drug binding to a receptor without activating it
Stabalizing Action
a drug cuasing a neutral reaction, neither stimulating nor depressing the system
Replacing Action
the accumulation of a substance in the system, such as a glycogen stored as carbohydrates
Direct Constructive Chemical Reaction
a drug producing beneficial results
therapeutic window
measures the dose required for the medication to be effective against the amount of it that would cause adverse side effects
duration of action
how long the drug will be effective in the body
affinity
the evolutionary relationship between a group of relative organisms
pharmacokinetics
the way drugs move THROUGH the body
pharmacology
the effects the drug has ON the body
pharmacology
the effects the drug has ON the body
bioavailability
the usable amount of the drug that reaches the body’s circulation
depends on route of administration
bioequivalent
when two drugs have the same bioavailability
same chemical form, just formulated differently - GENERICS
liberation
(mechanism of pharmacokinetics)
release of a drug from its pharmaceutical formulation
absorption
(mechanism of pharmacokinetics)
process of a drug entering the body
distrubution
(mechanism of pharmacokinetics)
the dispersion of a drug throughout the body’s fluid and tissue
metabolism
(mechanism of pharmacokinetics)
transformation of a drug’s compounds into drug metabolites
excretion
(mechanism of pharmacokinetics)
the elimination of a drug from the body
first-pass effect (definition)
drug’s metabolism is greatly diminished before its distributed into the circulatory system
first-pass effect happens in (2)
either the liver or the small intestine
ionized
charged
non-ionized
uncharged
pH <7
acidic
pH 7
neutral
pH >7
alkaline
passive diffusion
the inactive transport of biochemical substance without energy input
lipid-water partition
form of passive diffusion
drug molecule can cross over cell membranes via lipid pathway or a water channel
