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Field Quiz 2 > Pharmacodynamics > Flashcards

Pharmacodynamics Flashcards

General pharmacology and pharmacodynamics

1
Q

What are 4 sources of drugs?

A

plant, animals, mineral and chemical substances

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2
Q

What did the Federal Food, Drug and Cosmetic Act of 1938, 1952 and 1962 establish?

A

Pure Food and Drug Act, 1906

Purity, standards and labeling

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3
Q

What did the Comprehensive Drug Abuse Prevention and Control Act of 1970 establish?

A

Harrison Narcotics Act, 1914

Schedule of controlled substances

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4
Q

What did the Durham-Humphrey Amendments of 1928, 1951 establish?

A

Establish process of ordering and prescribing drugs

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5
Q

What did Kefauver- Harris Amendment of 1962 establish?

A

Proof of effectiveness

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6
Q

What is the responsibility of the FDA?

A

safety standards- production drugs, food, cosmetics

Regulates medical devices

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7
Q

What is the responsibility of DEA?

A

controlled substance laws

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8
Q

What is the responsibility of the FTC?

A

Protects consumes, truth-in-advertising laws

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9
Q

What are the 5 steps of safe and effective administration?

A

Drug- profile
Patient- history, current drugs
Pathology- assess pt- what is wrong?
Protocols- authorized to give without call
Technique- IM, IV, fast/slow push, repeat

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10
Q

What are the 6 rights?

A

Right patient, drug, dose, route, time, documentation

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11
Q

What are examples of enteral routes?

A

Oral, buccal, sublingual, rectal

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12
Q

What does parenteral route avoid? What are the benefits of this?

A

First pass effect. Avoiding the first pass effect leads to rapid and complete absorption with smaller doses

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13
Q

What are the four stages of pharmocokinetics?

A

Absorption
Distribution
Metabolism
Excretion

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14
Q

What are the three main factors affecting absorption?

A

Route of administration
pH and soluability
Form- solid, liquid, gas

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15
Q

What are the three locations of excretion?

A

Kidneys- urine
Liver- stool
Lungs- exhaled

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16
Q

What is TD50 and LD50?

A

Toxid dose in 50% of patients

Lethal dose in 50% of patients

17
Q

What are the factors altering drug responses?

A

Age of patient
General health- weight, renal/hepatic function, metabolic rate
Administration- dose and route

18
Q

What are the five main factors affecting distribution?

A

blood flow to target tissues
amount bound to plasma proteins
how quickly/efficiently cross cell membranes
disease states- kidney, liver, respiratory
blood brain barrier or other physiologic barriers

Field Quiz 2 (5 decks)

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