Pharmacodynamics

Question 1

Pharmacokinetics

Answer 1

What the body does to the drug

Question 2

Pharmacodynamics

Answer 2

What the drug does to the body

Question 3

What is the effect state also known as the biophase?

Answer 3

The area of the body where the drug engages in its receptor

Question 4

Does Vd fall under pharmacokinetics or pharmacodynamics?

Answer 4

Pharmacokinetics

Question 5

Does Potency fall under pharmacokinetics or pharmacodynamics?

Answer 5

Pharmacodynamics

Question 5

Does efficacy fall under pharmacokinetics or pharmacodynamics?

Answer 5

Pharmacodynamics

Question 6

Does half-lives fall under pharmacokinetics or pharmacodynamics?

Answer 6

Pharmacokinetics

Question 7

Does dose response curve slope fall under pharmacokinetics or pharmacodynamics?

Answer 7

pharmacodynamics

Question 8

Does metabolism fall under pharmacokinetics or pharmacodynamics?

Answer 8

pharmacokinetics

Question 9

pharmacokinetics

Question 10

Does enzyme induction and inhibition fall under pharmacokinetics or pharmacodynamics?

Answer 10

Pharmacokinetics

Question 11

Does clearance fall under pharmacokinetics or pharmacodynamics?

Answer 11

Pharmacokinetics

Question 12

Does agonist/antagonist/partial agonist/inverse agonist fall under pharmacokinetics or pharmacodynamics?

Answer 12

Pharmacodynamics

Question 13

Does steady state fall under pharmacokinetics or pharmacodynamics?

Answer 13

Pharmacokinetics

Question 14

Does context sensitive half time fall under pharmacokinetics or pharmacodynamics?

Answer 14

Pharmacokinetics

Question 15

Does degree of ionization fall under pharmacokinetics or pharmacodynamics?

Answer 15

Pharmacokinetics

Question 16

Does protein binding fall under pharmacokinetics or pharmacodynamics?

Answer 16

Pharmacokinetics

Question 17

Does ion trapping fall under pharmacokinetics or pharmacodynamics?

Answer 17

Pharmacokinetics

Question 18

Does metabolism fall under pharmacokinetics or pharmacodynamics?

Answer 18

Pharmacodynamics

Question 19

Does ED50 and TD50 fall under pharmacokinetics or pharmacodynamics?

Answer 19

Pharmacodynamics

Question 20

Does therapeutic index fall under pharmacokinetics or pharmacodynamics?

Answer 20

Pharmacodynamics

Question 21

Does stereochemistry fall under pharmacokinetics or pharmacodynamics?

Answer 21

Pharmacodynamics

Question 22

On the dose response curve where do efficacy and potency lie?

Answer 22

Efficacy on top
Potency on bottom

Question 23

ED50 and 90 are measures of what?

Answer 23

Potency

Question 24

Does a left or right shift curve represent a higher potency and lower dose required?

Answer 24

Left

Question 25

The height of the plateau of the dose response curve tells you about:

Answer 25

efficacy

Question 26

A taller plateau on the dose response curve means

Answer 26

Greater efficacy

Question 27

A shorter plateau on the dose response curve means

Answer 27

Decreased efficacy

Question 28

What does the slope tell us about how many receptors must be occupied before we observe the clinical response? What does a steep vs not steep slope tell us?

Answer 28

How many receptors must be occupied to observe the clinical response Steep: Most of -R must be occupied Not steep: Less -R must be occupied

Question 29

Are receptors up or down regulated with a continuous agonist? Antagonist?

Answer 29

down up

Question 30

Is Propanolol an antagonist, agonist or inverse agonist?

Answer 30

inverse

Question 31

What is potentiation? 1+0=3

Answer 31

When the effect of a drug that would not have an effect on its own is given with a drug that enhances it

Question 32

Which way does D enantiomer rotate?

Answer 32

Clock wise

Question 32

R and S molecules

Answer 32

R=right hand L=left hand

Question 32

Which way does L enatiomer rotate?

Answer 32

counter clockwise

Question 33

What do you need to know about R/S enantiomers of Bupivacaine and Ketamine?

Answer 33

S Bupi (less cardiotoxic) and S Ketamine (less likely to cause emergence deliurium)

Question 33

What are enantiomers?

Answer 33

Chiral compounds that are mirror images of each other

Question 34

What is a racemic mixture?

Answer 34

Has 2 enantiomers in equal amounts