Pharmaco Flashcards
1
Q
Pro drug
A
requires metabolism to become active for therapeutic affect
2
Q
Example or prodrugs
A
Codeine, Clopidogrel
3
Q
Active drug
A
already active for therapeutic effect; inactivated by metabolism
4
Q
example of active drug
A
warafin
5
Q
codeine gene
A
CYP2D6
6
Q
Clopidogrel gene
A
CYP2C19
7
Q
Wafarin gene
A
CYP2C9
8
Q
Genes that are phase 1 metabolism (ox-redox rxn)
A
CYP genes
9
Q
Somatic tumor specific variants
A
KRAS, BCR/ABL, EGFR, cKIT, BRAF, ALK
10
Q
CYP450 catalyze
A
redox rxns
11
Q
CYP450 are
A
predominately in liver
12
Q
more than 90% of all common drugs are metabolized by enzymes encoded by 6 CYP450 Genes:
A
CYP1A1, CY1A2, CYP2C9, CYC2C19, CYP2D6, CYP3A4
13
Q
Types of variants in pharm
A
SNPs, indels, CNVs
14
Q
*1
A
no variant detected
15
Q
Diplotype CYP2C191/17
A
Rapid metabolizer, 1 increased function, one normal copy
