Pharmaco

Question 1

Pro drug

Answer 1

requires metabolism to become active for therapeutic affect

Question 2

Example or prodrugs

Answer 2

Codeine, Clopidogrel

Question 3

Active drug

Answer 3

already active for therapeutic effect; inactivated by metabolism

Question 4

example of active drug

Answer 4

warafin

Question 5

codeine gene

Answer 5

CYP2D6

Question 6

Clopidogrel gene

Answer 6

CYP2C19

Question 7

Wafarin gene

Answer 7

CYP2C9

Question 8

Genes that are phase 1 metabolism (ox-redox rxn)

Answer 8

CYP genes

Question 9

Somatic tumor specific variants

Answer 9

KRAS, BCR/ABL, EGFR, cKIT, BRAF, ALK

Question 10

CYP450 catalyze

Answer 10

redox rxns

Question 11

CYP450 are

Answer 11

predominately in liver

Question 12

more than 90% of all common drugs are metabolized by enzymes encoded by 6 CYP450 Genes:

Answer 12

CYP1A1, CY1A2, CYP2C9, CYC2C19, CYP2D6, CYP3A4

Question 13

Types of variants in pharm

Answer 13

SNPs, indels, CNVs

Question 14

*1

Answer 14

no variant detected

Question 15

Diplotype CYP2C191/17

Answer 15

Rapid metabolizer, 1 increased function, one normal copy

Question 16

recommendations for high metabolizer of clopidogrel

Answer 16

no recommendation, use standard dose

Question 17

CYP2C19

Answer 17

Located on 10q23.33
over 39 alleles

Question 18

Clopidogrel medication

Answer 18

prevents platelet aggregation and inhibit blood clots
reduce risk of heart attack and stroke

Question 19

recommendation for intermediate or poor metabolizers in CYP2C19 + Clopidogrel

Answer 19

recommend alternative anti-platelet therapy

Question 20

Hawaiian lawsuit drug

Answer 20

Plavix