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Pharmaceutics Final > Pharmaceutics Final > Flashcards

Pharmaceutics Final Flashcards

1
Q

Accuracy

A

degree of conformity with a standard

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2
Q

Precision

A

degree of perfection within an instrument or method

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3
Q

Repeatability

A

Ability to get the same results under the same conditions, in the same, lab, on the same day

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4
Q

Reproducibility

A

Ability to get the same results under similar conditions on a different day, in a different laboratory

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5
Q

Analytical blank

A

All of the reagents involved in an assay except the analyte

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6
Q

Calibration

A

comparison of the value for a particular parameter to pre-set standards

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7
Q

detection limit

A

lowest amount of analyte that can be detected but not accurately quantified

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8
Q

quantitation limit

A

lowest amount of analyte that can be detected and quantitated accurately

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9
Q

linearity

A

ability to obtain results within a range that are directly proportional to conc of analyte

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10
Q

range

A

interval between upper and lower concentrations that the device can accurately measure

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11
Q

robustness

A

capacity to remain unaffected by small deliberate variations in experimental parameters

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12
Q

selectivity

A

ability to detect analyte alone in the presence of other compounds

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13
Q

sensitivity

A

ability to detect small changes in concentration of analyte

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14
Q

one point calibration

A

utilizes one standard, that is sufficiently reliable, as a comparison value to the analyte where interpolation can be made

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15
Q

multiple point calibration

A

three points other than zero that generate a comparison range where interpolation and extrapolation (if linear correlation is satisfactory), can ocurr

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16
Q

UV/Vis spectrophotometry

A

relationship between analyte and intensity of light absorption at a given wavelength

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17
Q

UV/Vis strength + weakness

A

Strength:
-easy, inexpensive, robust
weakness:
-poor selectivity, hard to analyze mixtures

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18
Q

beer lambert law

A 
A = ebc
A: absorbance
e: molar absorption coefficient
b: length of cell
c: concentration
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19
Q

spectrophotometric analysis can…

A

determine partition coefficient, solubility, and drug release/diffusion

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20
Q

isoproterenol Injection USP standards

A

may contain not less than 90% and not more than 115% of labelled amount

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21
Q

isoproterenol lab

  • isoproterenol
  • ferrous sulfate
  • aminoacetate
A

isoproterenol –> analyte
ferrous sulfate –>
aminoacetate –> buffer

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22
Q

phenytoin injection additives

A

10% alcohol

40% propylene glycol

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23
Q

phenytoin in NS and D5W

A

precipitated in all concentrations since aqueous solubility is so low

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24
Q

cloxacillin x gentamicin

A

precipitate

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25
Q

cefazolin x gentamicin

A

precipitate

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26
Q

ampicillin x gentamicin

A

no precipitate

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27
Q

penicillin G x gentamicin

A

no precipitate

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28
Q

tobramycin x cefazolin

A

precipitate

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29
Q

tobramycin x cloxacillin

A

precipitate

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30
Q

tobramycin x ampicillin

A

no precipitate

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31
Q

tobramycin x penicillin G

A

no precipitate

32
Q

phenytoin x benadryl

A

precipitate

33
Q

phenytoin x lidocaine

A

precipitate

34
Q

phenytoin x aminophylline

A

precipitate

35
Q

phenytoin x KCl

A

precipitate

36
Q

phenytoin x epinephrine

A

precipitate

37
Q

phenytoin x NaOH

A

no precipitate

38
Q

Benadryl x lidocaine

A

no precipitate

39
Q

Benadryl x aminophylline

A

precipitate

40
Q

Benadryl x KCl

A

no precipitate

41
Q

Benadryl x epinephrine

A

no precipitate

42
Q

Benadryl x NaOH

A

precipitate

43
Q

lidocaine x aminophylline

A

no precipitate

44
Q

lidocaine x KCl

A

no precipitate

45
Q

lidocaine x epinephrine

A

precipitate

46
Q

lidocaine x NaOH

A

precipitate

47
Q

lidocaine x HCl

A

no precipitate

48
Q

aminophylline x KCl

A

no precipitate

49
Q

aminophylline x HCl

A

no precipitate

50
Q

aminophylline x epinephrine

A

no precipitate

51
Q

aminophylline x NaOH

A

no precipitate

52
Q

KCl x HCl

A

no precipitate

53
Q

KCl x epinephrine

A

no precipitate

54
Q

KCl x NaOH

A

no precipitate

55
Q

HCL x epinephrine

A

no precipitate

56
Q

HCl x NaOH

A

no precipitate

57
Q

epinephrine x NaOH

A

precipitate

58
Q

diluents

A
  • to increase tablet mass

ex: dicalcium PO4, calcium sulfate, lactose, cellulose, mannitol, NaCl, starch, powdered sugar

59
Q

binders

A
  • to improve flowing properties of granules

ex: starch, sugar, acacia, sodium alginate, CMC

60
Q

lubricants

A
  • to prevent adhesion to dies and punches

ex: talc, magnesium stearate, oils, polyethylene glycol

61
Q

disintegrants

A
  • to absorb water and increase in size

ex: starch, cellulose, algins

62
Q

tablet hardness

A

to withstand chipping and abrasion

63
Q

friability

A

to withstand abrasion

64
Q

uniformity

A

ensuring each tablet contains the same amount of active ingredient

65
Q

disintegration

A

ability to break into small particles

66
Q

dissolution

A

time required for a given percentage of tablet to go into solution

67
Q

acetaminophen

A

active

68
Q

lactulose

A

diluent

69
Q

avicel

A

binder

70
Q

explotab

A

disintegrant

71
Q

magnesium stearate

A

lubricant

72
Q

talc

A

lubricant

73
Q

accelerated stability testing

A

collect data under extreme conditions and predict characteristics under normal circumstances

74
Q

accelerated test parameters

A

solid –> 25-37 degrees, 60-70 humidity x 30 days

liquid –> 40-90 degrees, 60-70 humidity x 30 days

75
Q

factors affecting diffusion

A

temperature, pressure, solvent properties, chemical nature

76
Q

chromatographic separation

A

adsorption, partition, solubility, vapor pressure, molecular size, ionic charge

77
Q

Rf

A

Rf = distance solute has moved / distance solvent front has moved

Pharmaceutics Final (1 decks)

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