Pharmaceuticals

Question 1

Sincalide dose (nuclear medicine)

Answer 1

0.02 micrograms/kg over 60 minutes (GBEF should be greater than 38)

Question 2

Morphine sulfphate dose (nuclear medicine)

Answer 2

0.02-0.04 mg/kg or a standard 2 mg dose over 30-60 minutes

Question 3

Dobutamine MOA and effects

Answer 3

B1 and B2 stimulation causing increased heart rate, blodo pressure and myocardial contractility

Question 4

Phenobarbital for biliary atresia (dose)

Answer 4

5mg/kg/day for 5 days

Question 5

Dipyridamole - MOA and Trivia

Answer 5

Inhibits the breakdown of adenosine - which builds up. Adenosine is a potent vasodilator.

No caffeine.

Question 6

Adenosine - MOA and Trivia

Answer 6

Vasodilator

No caffeine. Side effects are worse than with dipyrimadole. Rare side effect is AV block - which will get better when adenosine short half life runs out.

Question 7

Regadenoson - MOA and Trivia

Answer 7

Selective A2A - causes fever side effects

No caffeine.

Question 8

Dobutamine - MOA and Trivia

Answer 8

Beta 1 agonist - acts like exercise by increasing heart rate and myocardial contraction.

Patient can NOT be on a beta-blocker.

Best used in patients who cannot have adenosine or dipyrimadole. Better in patients with COPD or Asthma, or who have taken caffeine in the last 12 hours.

Avoid with LBBB

Question 9

Aminophylline - MOA and Trivia

Answer 9

Antidote for adenosine

Half life is shorter than Dipyrimadole - so must continue to monitor.

Question 10

Name the radiotracers used to treat bone pain.

Answer 10

Strontium (Sr89) - Metastron
Samarium (Sm153) - Quadramet
Radium (Ra223) - Xofigo