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PDF MIDTERM > PHARMACEUTICAL INSERTS > Flashcards

PHARMACEUTICAL INSERTS Flashcards

1
Q

are solid bodies of various weights and shapes, adapted for introduction into the rectal, vaginal, or urethral orifices of the human body.

A

suppository

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2
Q

are used to deliver drugs for their local or systemic effects.

A

suppository

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3
Q

What are the advantages of Suppositories?

A
  • Useful for patients who are unconscious and vomiting
  • Avoids 1st pass effect by the liver
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4
Q

1st pass effect

A

Presystemic Metabolism

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5
Q

Disadvantages of Suppo

A

Unpredictable
Variable absorption
Unacceptable to certain patients/culture

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6
Q

Type of Suppo

A

Rectal
Vaginal/Pessaries
Urethral/Bougies

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7
Q

SHAPE OF RECTAL

A

little finger
torpedo
bullet

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8
Q

SHAPE OF VAGINAL

A

cone
oviform
globular

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9
Q

SHAPES OF URETHRAL

A

pencil

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10
Q

WEIGHT OF RECTAL

A

Adults ; 2g
Pediatrics ; 1g

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11
Q

WEIGHT OF VAGINAL

A

5g

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12
Q

WEIGHT OF URETHRAL

A

male ; 4g
female ; 2g

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13
Q

SIZE OF RECTAL

A

Adults ; 32mm
Pediatrics ; 16mm

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14
Q

SIZE OF URETHRAL

A

Male ; 140 mm
Female ; 70 mm

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15
Q

GENERAL SPECIFICATIONS FOR SUPPOSITORY BASE

A

nontoxic
nonirritating
compatible
stable
melts , dissolve in the rectal fluids

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16
Q

3 GROUPS CLASSIFICATION OF SUPPOSITORY BASES

A

fatty / oleaginous base
water - soluble / water miscible base
Miscellaneous Base

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17
Q

a combination of lipophilic and hydrophilic subtances

A

MISCELLANEOUS BASE

18
Q

Obtained from Theobroma cacao

A

Cocoa Butter

19
Q

Widely used for rectal suppositories

A

Cocoa Butter

20
Q

MELTING POINT VARIATION of
gamma
alpha
beta prime
beta

A

Gamma (γ): ~18°C
Alpha (α): ~22°C
Beta Prime (β’): ~28°C
Beta (β): ~34.5°C

21
Q

Which is the ideal suppository base in the 4 melting points?

A

BETA - 34.5 C

  • close to body temparatue
22
Q

Wecobee Base

A

Derived from coconut oil triglycerides.

23
Q

Composed of triglycerides from saturated fatty acids (C12-C18).

A

Witepsol Base

24
Q

Major Component is LAURIC ACID

A

witepsol base

25
Q

Most frequently used in pessaries

A

GLYCERINATED GELATIN

26
Q

IT LIQUEFY

A

deliquescent

27
Q

it does not liquefy

A

hydroscopic

28
Q

PEG

A

POLYETHYLENE GLYCOL

29
Q

can be stored at usual room temperature 20 - 25

does not melt at body temperature but rather dissolved slowly in the body fluids

A

PEG

30
Q

Mixtures of oleaginous and water soluble/water miscible materials

A

MISCELLANOUS BASES

31
Q

Mixture of monostearate and distearate esters derived from polyoxyethylene.

A

Polyoxyl 40 Stearate cOMPOSITION

32
Q

POLYOXYL 40 STEARATE APPEARANCE

A

/ white to light tan waxy solid

33
Q

WATER SOLUBILITY OF POLYOXYL 40 STEARATE AND ME;LTING POINT

A

WATER SOLUBLE / MP ; 39 - 45 C

34
Q

2 PREPATION OF SUPPOSITORY

A

MOLDING
HAND ROLLING AND SHAPING

35
Q

Most frequently employed both on a small-scale and industrial use

A

MOLDING

36
Q

Oldest and simplest method

A

HAND ROLLING AND SHAPING

37
Q

Ovoid- or pear-shaped compressed tablets inserted into the vagina using a plastic inserter

For local and systemic use

A

VAGINAL TABLETS

38
Q

VAGIFEM

A

ESTRADIOL

39
Q

ANTIFUNGAL AND TREATMENT FOR CANDIDIASIS ( vaginal yeast infection)

A

NYSTATIN VAGINAL TABLETS

40
Q

Long acting dosage forms that provide continuous release of the drug often for periods of months to years.

They can be administered for local or systemic delivery

A

IMPLANTS

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