PHARMACEUTICAL INSERTS

Question 1

are solid bodies of various weights and shapes, adapted for introduction into the rectal, vaginal, or urethral orifices of the human body.

Answer 1

suppository

Question 2

are used to deliver drugs for their local or systemic effects.

Answer 2

suppository

Question 3

What are the advantages of Suppositories?

Answer 3

• Useful for patients who are unconscious and vomiting
• Avoids 1st pass effect by the liver

Question 4

1st pass effect

Answer 4

Presystemic Metabolism

Question 5

Disadvantages of Suppo

Answer 5

Unpredictable
Variable absorption
Unacceptable to certain patients/culture

Question 6

Type of Suppo

Answer 6

Rectal
Vaginal/Pessaries
Urethral/Bougies

Question 7

SHAPE OF RECTAL

Answer 7

little finger
torpedo
bullet

Question 8

SHAPE OF VAGINAL

Answer 8

cone
oviform
globular

Question 9

SHAPES OF URETHRAL

Answer 9

pencil

Question 10

WEIGHT OF RECTAL

Answer 10

Adults ; 2g
Pediatrics ; 1g

Question 11

WEIGHT OF VAGINAL

Answer 11

5g

Question 12

WEIGHT OF URETHRAL

Answer 12

male ; 4g
female ; 2g

Question 13

SIZE OF RECTAL

Answer 13

Adults ; 32mm
Pediatrics ; 16mm

Question 14

SIZE OF URETHRAL

Answer 14

Male ; 140 mm
Female ; 70 mm

Question 15

GENERAL SPECIFICATIONS FOR SUPPOSITORY BASE

Answer 15

nontoxic
nonirritating
compatible
stable
melts , dissolve in the rectal fluids

Question 16

3 GROUPS CLASSIFICATION OF SUPPOSITORY BASES

Answer 16

fatty / oleaginous base
water - soluble / water miscible base
Miscellaneous Base

Question 17

a combination of lipophilic and hydrophilic subtances

Answer 17

MISCELLANEOUS BASE

Question 18

Obtained from Theobroma cacao

Answer 18

Cocoa Butter

Question 19

Widely used for rectal suppositories

Answer 19

Cocoa Butter

Question 20

MELTING POINT VARIATION of
gamma
alpha
beta prime
beta

Answer 20

Gamma (γ): ~18°C
Alpha (α): ~22°C
Beta Prime (β’): ~28°C
Beta (β): ~34.5°C

Question 21

Which is the ideal suppository base in the 4 melting points?

Answer 21

BETA - 34.5 C

• close to body temparatue

Question 22

Wecobee Base

Answer 22

Derived from coconut oil triglycerides.

Question 23

Composed of triglycerides from saturated fatty acids (C12-C18).

Answer 23

Witepsol Base

Question 24

Major Component is LAURIC ACID

Answer 24

witepsol base

Question 25

Most frequently used in pessaries

Answer 25

GLYCERINATED GELATIN

Question 26

IT LIQUEFY

Answer 26

deliquescent

Question 27

it does not liquefy

Answer 27

hydroscopic

Question 28

PEG

Answer 28

POLYETHYLENE GLYCOL

Question 29

can be stored at usual room temperature 20 - 25 does not melt at body temperature but rather dissolved slowly in the body fluids

Answer 29

PEG

Question 30

Mixtures of oleaginous and water soluble/water miscible materials

Answer 30

MISCELLANOUS BASES

Question 31

Mixture of monostearate and distearate esters derived from polyoxyethylene.

Answer 31

Polyoxyl 40 Stearate cOMPOSITION

Question 32

POLYOXYL 40 STEARATE APPEARANCE

Answer 32

/ white to light tan waxy solid

Question 33

WATER SOLUBILITY OF POLYOXYL 40 STEARATE AND ME;LTING POINT

Answer 33

WATER SOLUBLE / MP ; 39 - 45 C

Question 34

2 PREPATION OF SUPPOSITORY

Answer 34

MOLDING HAND ROLLING AND SHAPING

Question 35

Most frequently employed both on a small-scale and industrial use

Answer 35

MOLDING

Question 36

Oldest and simplest method

Answer 36

HAND ROLLING AND SHAPING

Question 37

Ovoid- or pear-shaped compressed tablets inserted into the vagina using a plastic inserter For local and systemic use

Answer 37

VAGINAL TABLETS

Question 38

VAGIFEM

Answer 38

ESTRADIOL

Question 39

ANTIFUNGAL AND TREATMENT FOR CANDIDIASIS ( vaginal yeast infection)

Answer 39

NYSTATIN VAGINAL TABLETS

Question 40

Long acting dosage forms that provide continuous release of the drug often for periods of months to years. They can be administered for local or systemic delivery

Answer 40

IMPLANTS