Pharmaceutical and Radiopharmaceutical Agents

Question 1

A biohazard warning label would be found on all the following except a?
a) Contaminated sharps container
b) Refrigerator containing potentially infectious material.
c) Receptable for contaminated laundry
d) Unit of blood released for clinical use.

Answer 1

d) Unit of blood released for clinical use.

Question 2

For HIDA scan to evaluate biliary atresia, which of the following is not correct?
a) It’s most commonly performed in newborn infants.
b) Biliary atresia is characterized by obliteration of the extrahepatic biliary system
c) If no bowel activity is visualized, 4hr delayed imaging is required to complete the study
d) If no bowel activity is visualized, 24hr delayed imaging is required to complete the study.

Answer 2

c) If no bowel activity is visualized, 4hr delayed imaging is required to complete the study

Question 3

The most appropriate dose to inject for imaging inflammation with In111-labeled leukocytes is?
a) 0.5 - 1.0mCi
b) 2.0 - 4.0mCi
c) 5 - 10mCi
d) 6 - 8mCi

Answer 3

c) 0.5-1.0mCi

Question 4

To evaluate suspected infection in pediatric patients…..is preferred because of…..?
a) 111-In-WBC scan, better image quality
b) 111-In-WBC scan, lower dose
c) Tc99m-WBC scan, better image quality
d) Tc99m-WBC scan, lower radiation

Answer 4

d) Tc99m-WBC scan, Lower radiation

Question 5

The highest physiologic activity on the In111-WBC scan is noted at?
a) Liver
b) Spleen
c) Bone marrow
d) GI tract

Answer 5

b) Spleen

Question 6

Which of the following is not correct regarding the recommended dose and waiting period before Amyloid PET image acquisition?
a) 18F-florbetapir, dose of 370MBq(10mCi), waiting period of 45min
b) 18F-flutemetamol, dose of 185MBq(5mCi), waiting period of 90min
c) 18F-florbetapir, dose of 370MBq(10mCi), waiting period of 120min
d) 18F-florbetaben, dose of 300MBq(8mCi), waiting period of 120min

Answer 6

c) 18F-Florbetapir, dose of 370 Mbq (10mCi), waiting period of 120min

Question 7

For pharmacologic stress tests, which of the following has the shortest half-life?
a) Adenosine
b) Dipyridamole
c) Regadenoson
d) Dobutamine

Answer 7

a) Adenosine

Question 8

To perform a sestamibi myocardial perfusion study, which of the following is not correct?
a) NPO overnight or at least 4hr
b) No coffee or tea at least 12 hours before the study for the Lexiscan test.
c) No coffee or tea at least 12 hours before the study for the Persantine test.
d) No coffee or tea at least 12 hours before the study for the treadmill test.

Answer 8

d) No coffee or tea at least 12 hours before the study for the treadmill test.

Question 9

After injection of I125 human serum albumin for determination of plasma volume, it’s important to withdraw a small amount of blood into the syringe and reinject it, to ensure that the entire radioactive dose is administered.?
a) True
b) False

Answer 9

b) False

Question 9

Cimetidine
a) Prevents the gallbladder from contracting
b) Prevents the release of pertechnetate from gastric mucosa
c) Increases uptake of pertechnetate in the gastric mucosa
d) Decreases peristalsis

Answer 9

b) Prevents the release of pertechnetate from gastric mucosa

Question 10

What is the purpose of adding Hetastarch to a blood sample drawn for the purpose of leukocyte labeling?
a) To act as an anticoagulant
b) To hasten the settling of Erythrocytes
c) To separate platelets from leukocytes
d) To improve labeling efficiency

Answer 10

b) To hasten the settling of erythrocytes

Question 11

The molecule name for Pluvicto is Lu-177 Lutathera.?
a) True
b) False

Answer 11

b) False

Question 12

What is the brand name for FES(Fluororestradiol)?
a) Axumin
b) Pylarify
c) Cerianna
d) Dotatate

Answer 12

c) Cerianna

Question 13

What can be used besides Dobutamine if the target heart rate is not reached?
a) Lexiscan
b) Aminophylline
c) Atropine
d) Persantine

Answer 13

c) Atropine

Question 14

A technologist must administer 8mCi Tc99m mebrofenin to a patient at 1100. Based on the vial label information what volume should be given?
Cali: 0700
Total Activ: 100mCi
Total Vol: 8.5mL
Concent: 11.8mCi/mL
Expir: 1500
a) 1.1mL
b) 11.76mL
c) 0.86mL
d) 1.48mL

Answer 14

a) 1.1mL

Question 15

What are the methods of localization for In111-Oxine, except?
a) Lipid-soluble
b) Disassociate to allow binding to intracellular proteins, it becomes trapped
c) Phagocytosis by the kupffer cells.
d) Oxine diffuses out of the cell and it washes away during labeling

Answer 15

c) Phagocytosis by the kupffer cells.