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Entrance > Pharmac > Flashcards

Pharmac Flashcards

0
Q

Ccr5 inhibitor

A

Maraviroc

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1
Q

Gp41 inhibitor

A

Enfuvirtide

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2
Q

Non nucleoside reverse transcriptase inhibitor

A

Efavirenz

Nevirepine

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3
Q

Nucleotide reverse transcriptase inhibitor

A

Tenofovir

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4
Q

Nucleoside reverse transcriptase inhibitor

A

Zidovudine
Didanosine
Stavudine
Abacavir

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5
Q

Integrase inhibitor

A

Raltegravir

Elvitagravir

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6
Q

Protease inhibitor

A

Saquinavir
Ritonavir
Indinavir

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7
Q

Alkylating agents - nitrogen mustards

A 
Mechlorethamine
Melphalan
Chlorambucil
Cyclophosphamide
Ifosamide
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8
Q

Alkylating agents - nitrosoureas

A

Carmustine

Lomustine

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9
Q

Alkylating agents ethylene amine

A

Thio TEPA

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10
Q

Alkylating agents alkyl sulfonates

A

Busulfan

Adv effect pulmonary fibrosis

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11
Q

Adv effect of cyclophosphamide

A

Causes hemorrhagic cystitis

Treat with mesna

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12
Q

Platinum containing analogues

A

Cisplatin

Carboplatin

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13
Q

Antimetabolites

A

Folate antagonists - a) methotrexate pemetrexed
Purine antagonists a) 6 mercaptopurine b) 6 thioguanine , axathioprim , fludarabine
Pyramidine antagonists - 5 flourouracil , gemsitabine , cytarabine

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14
Q

Microtubule damaging drugs

A

Vinka alkaloids Prevents microtu ule formation vinblastin , vincristine

Taxanes - preventa depolymerisation of microtubule palcitaxel , docetaxel

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15
Q

Topoisomerase 1 inhibitor

A

Topotecan , irinotecan

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16
Q

Topoisomerase 2 inhibitor

A

Etoposide

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17
Q

Alkylating agents - triazines

A

Dacarbazine

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18
Q

Adv effects of terracyclines

A

KAPIL DEV
Kidney disease, antiandrogenic actions,photosensitivity,diabetes insipidus , liver toxicity , dentition stains , expired drugs cause fanconis syndrome , vestibular toxicity(max with minocycline)

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19
Q

Drugs excreted through kidney

A

BOAST

Beta lactam antibiotics, wuinolones , aminoglycosides , amphotericin b , sulfonamides , tetracycline except doxy

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20
Q

Drugs excreted thru bile

A

METABOLISM Can Prevent Dose Adjustment In Renal Diseases -
Metronidazole , erythromycin , ceftriaxone , azithromycin , novobiocin , linezolid , isoniazid , stretogramins , moxyfloxacin, clindamycin , cefoperazone, doxy, ampicillin , nafcillin, rifampin , chloramphenicol

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21
Q

Drugs causing constipation

A

Very Much Tough

Verapamil , MAO inhibitors , tricyclic anti depressants , frusemide

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22
Q

Antidiabetic - glp analogues

A

Exenatide

Livaglutide given parenteral

23
Q

Antidiabetic parenteral - amyline derivatives

A

Pramlintide

24
Q

Drugs following zero order kinetics

A

Zero WATT Power

Warfarin , alcohol, aspirin, theophylling , tolbutamide , phenytoin

25
Q

Phase one reactions

A

ORH

Oxidation reduction hydrolysis cyclization decyclization

26
Q

Phase 2 ( also called synthetic)

A

Glucuronide conjugation acetylation methylation sulfonation

27
Q

Enzyme inducers

A

GPRS Cell Phone

Gresiofulvin phenytoin. Rifampin. Smoking. Carbamazepine. Phenobarbitone

28
Q

Enzyme inhibitors

A

VIT K Cannot Cause Enzyme Inhibition

Valproate. Ketoconazole cimetenide ciprofloxacin. Erythromycin. INH.

29
Q

Anticoagulants parenteral

A

Directly acting thrombin inhibitors - hirudin lepirudin
Indirectly acting - heparin . Low molecular weight heparin. Fondaparinux. Idriaparinux( these two act agaisnt factor 10 a)

30
Q

Oral anticoagulants

A

Vit k inhibitors - warfarin. Dicumarol. Phenindione
Factor 10a inhibitors - rivaroxaban. Apixaban
Direct thrombin inhibitor - dabigatranetexilate

31
Q

Adv effects of amiodarone

A

The Periphery of My Lung Liver Cornea is Photosensitive
Thyroid. Peripheral neuropathy. Myocardial depression. Lung fibrosis. Liver toxicity. Corneal microdeposits. Photosensitivity

32
Q

Longest acting ocular beta blocker

A

Betaxolol

33
Q

Weak acids

A 
Barbiturates
NSAIDS
methotrexate
Sulfonamides
Pencillins
34
Q

Weak bases

A 
Morphine 
Atropine
Amphetamines
Quinines
Hyoscine
35
Q

Drugs with high first pass metabolism

A

Nitrates Have Large Pre Systemic Metabolism

Nitrates. Hydrocortisone. Lignocaine. Propranalol. Salbutamol. Morphine

36
Q

Drugs with high plasma protein bindin

A

Bnzodiazepines. Chlorpropamide. Tolbutamide. Cyclosporine. Fluoxetine. Imipramine. Verspamil. Warfarin

37
Q

Dialysis is not effective in

A

AVOIDD

Amphetamines. Verapamil. Op. Opoids. Imipramine. Digitalis. Diazepam

38
Q

Drugs showin acetylation

A

SHIP

SULFONAMIDES. hydralazine. Isoniazid. Procainamide

39
Q

Secondary messengers

A

Hydrophobic - DAG. IP3. Phosphotidlyinositol
Hydrophilic- cAMP. cGMP
GASES- NO. CO

40
Q

Druga to be avoided in g6pd deficiency

A 
Primaquine  
Quinine 
Chloroquine
Sulfamethoxazole
Nitrofurantoin
41
Q

Drugs with high first pass metabolism

A

Nitrates Have Large Pre Systemic Metabolism

Nitrates. Hydrocortisone. Lignocaine. Propranalol. Salbutamol. Morphine

42
Q

Drugs with high plasma protein bindin

A

Bnzodiazepines. Chlorpropamide. Tolbutamide. Cyclosporine. Fluoxetine. Imipramine. Verspamil. Warfarin

43
Q

Dialysis is not effective in

A

AVOIDD

Amphetamines. Verapamil. Op. Opoids. Imipramine. Digitalis. Diazepam

44
Q

Drugs showin acetylation

A

SHIP

SULFONAMIDES. hydralazine. Isoniazid. Procainamide

45
Q

Secondary messengers

A

Hydrophobic - DAG. IP3. Phosphotidlyinositol
Hydrophilic- cAMP. cGMP
GASES- NO. CO

46
Q

Druga to be avoided in g6pd deficiency

A 
Primaquine  
Quinine 
Chloroquine
Sulfamethoxazole
Nitrofurantoin
47
Q

Contraindications of digitalis

A

Contraindicated In Weak HEART

carditis. Increased calcium. WPW syndrome. Hypokalemia hypomagnesemia. Av block. Renal failure. Thyroid hypo n hyper

48
Q

Alter cel wal permeability

A

Polymixins. Bacitracin. Amphotericin B

49
Q

Inhibit cell wall synthesis

A

Pencillins. Cephalosporins. Vancomycin

50
Q

Inhibit protein synthesis

A

ProTEC

tetracycline erythromycin. Chloramphenicol

51
Q

Interfere with dna function

A

Rifampicin. Metronidazole

52
Q

Misleadin of mrna

A

Aminoglycosides. Streptomycin

53
Q

Interfere wih dna synthesis

A

Anti virals

54
Q

Inhibit dna gyrase

A

Flourquinolones. Coprofloxacin

55
Q

Drugs not to b given by IV

A

Paracetamol
Diclofenac
Choloquine
Adrenaline

Entrance (7 decks)

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