pharmaa

Question 1

Py12 ADP receptor inhibitors are:

Answer 1

ticlopidine, ticagrelol, prasugrel,colpidogrel

Question 2

gp2b/3a blockers are:

Answer 2

abciximab, tirofiban, eptifibatide

Question 3

antiplatelets agents that increase cAMP:

Answer 3

dipyridamole & cilostazol

Question 4

Aspirin dose is

Answer 4

325mg

Question 5

aspirin can be used in which prophylaxis type:

Answer 5

Primary & Secondary

Question 6

Py12 ADP antagonists inhibit

Answer 6

activation of gp2b/3a

Question 7

ADP antagonist most potent drugs are:

Answer 7

prasugrel, ticagrelor

Question 8

which ADP antagonist binds reversibly

Answer 8

ticagrelor

Question 9

ticlopidine is structurally similar to:

Answer 9

clopidogrel

Question 10

ticlopidine is used in

Answer 10

secondary prophylaxis of TIA & strokes

Question 11

in acute coronary syndrome we use :

Answer 11

prasugrel & ticagrelor

Question 12

Clopidogrel dose in NSTEMI

Answer 12

300mg loading + 75 daily +75-325 mg of aspirin daily

Question 13

clopidogrel dose in STEMI & stroke:

Answer 13

75 daily + 75-325 aspirin daily

Question 14

Food interferes with which one of the drugs:

Answer 14

Ticlopidine

Question 15

which drug is dose-dependent:

Answer 15

clopidogrel

Question 16

clopidogrel is a prodrug that is activated in liver what kind of drugs inhibit its activation

Answer 16

omeprazole which is an antacid cause failure of treatment

Question 17

S/E of ADP antagonists:

Answer 17

increase bleeding tendency

Question 18

Ticlopidine might cause

Answer 18

Neutropenia(agranulocytosis), TTP, Aplastic anaemia

Question 19

Which drug of ADP antagonists is C/I with aspirin:

Answer 19

Ticlopidine

Question 20

Prasugrel & Ticagrelor are C/I in:

Answer 20

TIA or stroke because of high incidence of brain haemorrhage

Question 21

abciximab, eptifibatide & tirofiban are given

Answer 21

IV

Question 22

We can use gp2a/3b with heparin and aspirin for pts with:

Answer 22

PCI or unstable angina when PCI is planned in 24 hours

Question 23

time to reach maximum efficacy of abciximab is

Answer 23

30 min & it’s given as a bolus then infusion

Question 24

drugs that are cleared immediately after stopping them are:

Answer 24

eptifibatide&tirofiban while abciximab stays in the blood for 24-48 hours after stopping it

Question 25

which drug cant work alone at all?

Answer 25

dipyridamole is used in combination with aspirin to prevent strokes

Question 26

dipyridamole is used with warfarin

Answer 26

to prevent thrombus because of prosthetic valves

Question 27

why is dipyridamole C/I in unstable angina

Answer 27

because of vasodilation which increase coronary steal syndrome

Question 28

side effects of vasodilation are

Answer 28

headache and orthostatic hypotension

Question 29

cilostazol is given

Answer 29

orally

Question 30

MOA of cilostazol is

Answer 30

Inhibition of phosphodiesterase III which increase cAMP

Question 31

cilostazol is used to reduce symptoms of

Answer 31

intermittent claudication

Question 32

cilostazol is C/I in pts with heart failure:

Answer 32

because increased cAMP makes the heart more contractile and causes increased workload which leads to death.