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Hematolymphoid system > pharmaa > Flashcards

pharmaa Flashcards

1
Q

Py12 ADP receptor inhibitors are:

A

ticlopidine, ticagrelol, prasugrel,colpidogrel

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2
Q

gp2b/3a blockers are:

A

abciximab, tirofiban, eptifibatide

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3
Q

antiplatelets agents that increase cAMP:

A

dipyridamole & cilostazol

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4
Q

Aspirin dose is

A

325mg

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5
Q

aspirin can be used in which prophylaxis type:

A

Primary & Secondary

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6
Q

Py12 ADP antagonists inhibit

A

activation of gp2b/3a

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7
Q

ADP antagonist most potent drugs are:

A

prasugrel, ticagrelor

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8
Q

which ADP antagonist binds reversibly

A

ticagrelor

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9
Q

ticlopidine is structurally similar to:

A

clopidogrel

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10
Q

ticlopidine is used in

A

secondary prophylaxis of TIA & strokes

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11
Q

in acute coronary syndrome we use :

A

prasugrel & ticagrelor

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12
Q

Clopidogrel dose in NSTEMI

A

300mg loading + 75 daily +75-325 mg of aspirin daily

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13
Q

clopidogrel dose in STEMI & stroke:

A

75 daily + 75-325 aspirin daily

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14
Q

Food interferes with which one of the drugs:

A

Ticlopidine

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15
Q

which drug is dose-dependent:

A

clopidogrel

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16
Q

clopidogrel is a prodrug that is activated in liver what kind of drugs inhibit its activation

A

omeprazole which is an antacid cause failure of treatment

17
Q

S/E of ADP antagonists:

A

increase bleeding tendency

18
Q

Ticlopidine might cause

A

Neutropenia(agranulocytosis), TTP, Aplastic anaemia

19
Q

Which drug of ADP antagonists is C/I with aspirin:

A

Ticlopidine

20
Q

Prasugrel & Ticagrelor are C/I in:

A

TIA or stroke because of high incidence of brain haemorrhage

21
Q

abciximab, eptifibatide & tirofiban are given

A

IV

22
Q

We can use gp2a/3b with heparin and aspirin for pts with:

A

PCI or unstable angina when PCI is planned in 24 hours

23
Q

time to reach maximum efficacy of abciximab is

A

30 min & it’s given as a bolus then infusion

24
Q

drugs that are cleared immediately after stopping them are:

A

eptifibatide&tirofiban while abciximab stays in the blood for 24-48 hours after stopping it

25
Q

which drug cant work alone at all?

A

dipyridamole is used in combination with aspirin to prevent strokes

26
Q

dipyridamole is used with warfarin

A

to prevent thrombus because of prosthetic valves

27
Q

why is dipyridamole C/I in unstable angina

A

because of vasodilation which increase coronary steal syndrome

28
Q

side effects of vasodilation are

A

headache and orthostatic hypotension

29
Q

cilostazol is given

A

orally

30
Q

MOA of cilostazol is

A

Inhibition of phosphodiesterase III which increase cAMP

31
Q

cilostazol is used to reduce symptoms of

A

intermittent claudication

32
Q

cilostazol is C/I in pts with heart failure:

A

because increased cAMP makes the heart more contractile and causes increased workload which leads to death.

Hematolymphoid system (2 decks)

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