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Biochem > Pharma In Biochem > Flashcards

Pharma In Biochem Flashcards

1
Q

Inhibits HMG CoA reductase

Tx for hypercholesterolemia

A

Statins

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2
Q

Anti inflammatory inhibits phospholipase A2 and decreas the production of arachidonic acid

A

Steroids

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3
Q

Decrease inflammation by REVERSIBLY inhibiting cox

A

NSAIDS

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4
Q

Decrease inflammation by slectivley inhbiting cox2

A

Celecoxib, etoricoxib ( may aggravate heart failure)

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5
Q

Irreversible inhibits cox

A

Aspirin

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6
Q

Decrease inflammation in BA by inhibiting lipoxygenase

A

Zileuton

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7
Q

Inhibit leukotriene receptors in BA

A

Monteleukast

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8
Q

Oral anti diabetic reduce postprandial hyperglycemia by inhibiting the conversion of starch, oligosaccharides, dissacharides, into monosaccharides

A

Alpha glucosidase inhibitor(acarbose, miglitol)

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9
Q

Antibiotics interfere with bacterial DNA synthesis by competitively inhibiting dihydropteroate synthase

A

Sylfonamides

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10
Q

Antibiotic interferes with bacterial DNA synthesis inbits dihydrofolate reductase

A

Trimethoprim

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11
Q

Antibiotic interfere with bacterial DNA synthesis inhibits topoisomerase type ii

A

Fluoroquinolones (ciprofloxacin, ofloxacin, levolfoxacin, moxifloxacin)

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12
Q

Antineoplastic amd imminosuppressant inhibits duhydrofolate reductase

A

Methotrexate

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13
Q

Antineoplastic inhibits thymidykate synthase and causes thumineless cell death

A

5- flurouracil

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14
Q

Antimycobacterial inhibits DNA dependent RNA polymerase

A

Rifampicin

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15
Q

Antibiotic inhibits prokaryotic peptidyltransferase and peptide bond formation

A

Chloramphenicol

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16
Q

Antibiotic prvents binding of aminoacyl tRNA to the A site

A

Tetracycline

17
Q

Antibiotics that bind to 30S subunit and block the formationof initiation complex

A

Aminoglycosides

18
Q

These antibiotics bind to the 50s subunit and inhibit translocation

A

Clindamycin and macrolides

19
Q

Inhibits xanthine oxidase

Treat gout

A

Allopurinol for over producers

Given 14-21 days post attack

Biochem (5 decks)

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