[PHARMA] HYPOTHALAMUS & PITUITARY Flashcards

1
Q

Recombinant GH

A

somatotropin

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2
Q

somatostatin analog

A

octreotide

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3
Q

synthetic ACTH

A

Cosynotropin

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4
Q

orally active DA

A

Bromocriptine

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5
Q

somatotropin uses

A

promotes growth
anti-aging
increases performance

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6
Q

somatotropin side effects (4)

A

hyperglycemia
edema
myalgia
ENZYME INDUCER

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7
Q

Enzyme inducer

A

somatotropin

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8
Q

octreotide characteristics

A

long t1/2
SC
somatostatin analog

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9
Q

octreotide uses (6)

A

1-VIP secreting gastric tumors
2-gastrinomas
3-glucagonomas
4-acromegaly
5-bleeding esophageal varices
6-carcinoid syndrome

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10
Q

octreotide adverse effects (4)

A

1-gall stones
2-nausea, vomiting, cramps
3-Vitamin B12 deficiency
4-pain at site of injection

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11
Q

syntocinon antagonist

A

Atisoban

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12
Q

can cause orthostatic hypotension

A

bromocriptine

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13
Q

can cause Vitamin B12 deficiency

A

octreotide

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14
Q

DOC in bleeding esophageal varices

A

octreotide

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15
Q

drugs used in acromegaly

A

octreotide
bromocriptine
cosynotropin

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16
Q

PRL inhibiting drug

A

bromocriptine

17
Q

bromocriptine characteristics

A

orally active DA
(-) PRL
↑ GH in normal conditions
↓ GH in acromegaly

18
Q

Bromocriptine uses (7)

A

1-PRL secreting adenomas
2-Amenorrhea
3-Galactorrhea
4-Infertility
5- (-) Lactation & breast engorgement
6- Parkinsonism
7-Acromegaly

19
Q

Bromocriptine adverse effects

A

1-Nausea
2-Confusion
3-orthostatic hypotension

20
Q

cosynotropin uses

A

1-adrenocortical insufficiency screening
2-Duchene muscle dystrophy
3- Infantile spasm

21
Q

cosynotropin uses (3)

A

1-adrenocortical insufficiency screening
2-Duchene muscle dystrophy
3- Infantile spasm

22
Q

syntocinon uses (3)

A

1-induction of labor: uterine enertia, incomplete labor (IV)
2-Postpartum Hg (IM)
3-impaired milk ejection (nasal spray)

23
Q

syntocinon toxicity (3)

A

1-uterine rupture
2-fetal asphyxiation
3-water retention + intoxication

24
Q

used in Duchene muscle dystrophy

A

cosyntropin

25
Q

cardiac patients-safe antidiuretic drug

A

Felypressin

26
Q

prolongs action of LA

A

Terlipressin

27
Q

Terlipressin uses (3)

A

1-bleeding esophageal varices
2-surgery in portal HT
3-prolong LA action

28
Q

desmopressin acts on

A

V2 receptors

29
Q

Terlipressin & Felypressin act on

A

V1 receptors

30
Q

Desmopressin uses

A

1-ADH- sensitive diabetes insipidus
2-Nocturnal enuresis
3-Haemophilia A
4- Von Willebrand disease

31
Q

ADH analogues adverse effects (4)

A

1-VC: facial pallor, coronary spasm, ↑ BP
2-Colic
3-Allergic reactions
4-Water intoxication

32
Q

CI in case of ADH analogues

A

drug inducers
carbamazepine

33
Q

Desmopressin characteristics (5)

A

1-intra-nasal
2-preferred to ADH
3-longer acting
4-more potent
5-minimal VC

34
Q

ADH antagonist example

A

Vaptans

35
Q

Vaptans uses

A

SIADH
CHF
Euvolemic & hypervolemic hyponatremia

36
Q

conivaptan

A

IV
non selective
V1 + V2 antagonist

37
Q

Tolvaptan

A

Oral
selective
V2 antagonist