[PHARMA] HYPOTHALAMUS & PITUITARY

Question 1

Recombinant GH

Answer 1

somatotropin

Question 2

somatostatin analog

Answer 2

octreotide

Question 3

synthetic ACTH

Answer 3

Cosynotropin

Question 4

orally active DA

Answer 4

Bromocriptine

Question 5

somatotropin uses

Answer 5

promotes growth
anti-aging
increases performance

Question 6

somatotropin side effects (4)

Answer 6

hyperglycemia
edema
myalgia
ENZYME INDUCER

Question 7

Enzyme inducer

Answer 7

somatotropin

Question 8

octreotide characteristics

Answer 8

long t1/2
SC
somatostatin analog

Question 9

octreotide uses (6)

Answer 9

1-VIP secreting gastric tumors
2-gastrinomas
3-glucagonomas
4-acromegaly
5-bleeding esophageal varices
6-carcinoid syndrome

Question 10

octreotide adverse effects (4)

Answer 10

1-gall stones
2-nausea, vomiting, cramps
3-Vitamin B12 deficiency
4-pain at site of injection

Question 11

syntocinon antagonist

Answer 11

Atisoban

Question 12

can cause orthostatic hypotension

Answer 12

bromocriptine

Question 13

can cause Vitamin B12 deficiency

Answer 13

octreotide

Question 14

DOC in bleeding esophageal varices

Answer 14

octreotide

Question 15

drugs used in acromegaly

Answer 15

octreotide
bromocriptine
cosynotropin

Question 16

PRL inhibiting drug

Answer 16

bromocriptine

Question 17

bromocriptine characteristics

Answer 17

orally active DA
(-) PRL
↑ GH in normal conditions
↓ GH in acromegaly

Question 18

Bromocriptine uses (7)

Answer 18

1-PRL secreting adenomas
2-Amenorrhea
3-Galactorrhea
4-Infertility
5- (-) Lactation & breast engorgement
6- Parkinsonism
7-Acromegaly

Question 19

Bromocriptine adverse effects

Answer 19

1-Nausea
2-Confusion
3-orthostatic hypotension

Question 20

cosynotropin uses

Answer 20

1-adrenocortical insufficiency screening
2-Duchene muscle dystrophy
3- Infantile spasm

Question 21

cosynotropin uses (3)

Answer 21

1-adrenocortical insufficiency screening
2-Duchene muscle dystrophy
3- Infantile spasm

Question 22

syntocinon uses (3)

Answer 22

1-induction of labor: uterine enertia, incomplete labor (IV)
2-Postpartum Hg (IM)
3-impaired milk ejection (nasal spray)

Question 23

syntocinon toxicity (3)

Answer 23

1-uterine rupture
2-fetal asphyxiation
3-water retention + intoxication

Question 24

used in Duchene muscle dystrophy

Answer 24

cosyntropin

Question 25

cardiac patients-safe antidiuretic drug

Answer 25

Felypressin

Question 26

prolongs action of LA

Answer 26

Terlipressin

Question 27

Terlipressin uses (3)

Answer 27

1-bleeding esophageal varices 2-surgery in portal HT 3-prolong LA action

Question 28

desmopressin acts on

Answer 28

V2 receptors

Question 29

Terlipressin & Felypressin act on

Answer 29

V1 receptors

Question 30

Desmopressin uses

Answer 30

1-ADH- sensitive diabetes insipidus 2-Nocturnal enuresis 3-Haemophilia A 4- Von Willebrand disease

Question 31

ADH analogues adverse effects (4)

Answer 31

1-VC: facial pallor, coronary spasm, ↑ BP 2-Colic 3-Allergic reactions 4-Water intoxication

Question 32

CI in case of ADH analogues

Answer 32

drug inducers carbamazepine

Question 33

Desmopressin characteristics (5)

Answer 33

1-intra-nasal 2-preferred to ADH 3-longer acting 4-more potent 5-minimal VC

Question 34

ADH antagonist example

Answer 34

Vaptans

Question 35

Vaptans uses

Answer 35

SIADH CHF Euvolemic & hypervolemic hyponatremia

Question 36

conivaptan

Answer 36

IV non selective V1 + V2 antagonist

Question 37

Tolvaptan

Answer 37

Oral selective V2 antagonist