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Pharma Antibiotics Flashcards

1
Q

CHON synthesis inhibitor at 50s subunit used in meningitis because it crosses BBB

A

Chloramphenicol

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2
Q

Only macrolide that doesn’t inhibit CYP450

A

Azithromycin

Also has highest Vd and slowest elimination

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3
Q

Bacteriostatic drug that binds to 50s subunit that causes serotonin syndrome as an adverse effect

A

Linezolid

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4
Q

Most important drug in TB; inbihit mycolic acid synthesis

A

Isoniazid

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5
Q

Bactericidal antibiotics

A 
Vancomycin
Fluoroquinolones
Penicillins
Aminoglycosides
Metronidazole
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6
Q

Most vestibulotoxic and nephrotoxic aminoglycosides

A

Tobramycin

Gentamycin

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7
Q

Aminoglycoside for drug redistant gonorrhea

A

Spectinomycin

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8
Q

Antimycobacterial that inhibit arabinosyl transferase

A

Ethambutol

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9
Q

3rd gen cephalosporins with disulfiram reaction

A

Cefoperazone

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10
Q

Most ototoxic aminoglycoside

A

Kanamycin

Amikacin

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11
Q

Ototoxicity in aminoglycosides is aggravated when used with?

A

Loop diuretics

Cisplatin

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12
Q

Bacteriostatic inhibitors of folic acid synthesis by competitively inhibiting dihydropteroate synthase

A

Sulfonamides

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13
Q

Cardiotoxic 3rd gen fluoroquinolone

A

Grepafloxacin

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14
Q

Action of rifampicin

A

Inhibit DNA dependent RNA polymerase

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15
Q

Fluoroquinolones block bacterial DNA synthesis by inhibiting ____________ in gram negative organisms and _____________ in gram positive organisms

A

Topoisomerase II (DNA gyrase)

Topoisomerase IV

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16
Q

Antimetabolite class of drug that blocks D-Ala incorporation into the pentapeptide chain of Peptidoglycan

A

Cycloserine

2nd line drug for MDR TB

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17
Q

Aminoglycosides with the narrowest therapeutuc window

A

Amikacin

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18
Q

Penicillin class for staph infection that is resistant to B-lactamase inhibition

A

Methicillin
Nafcillin
Oxacillin
Cloxacillin

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19
Q

Most hepatotoxic anti-TB drug? cidal or static?

A

Pyrazinamide

Bacteriostatic but can be bactericidal on actively dividing mycobacteria

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20
Q

Drug MOA is inhibition by binding to thr D-Ala-D-Ala terminus of nascent peptidoglycan

A

Vancomycin

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21
Q

Used in sulfone resistant leprosy? MOA?

A

Clofazimine

Binds to guanine bases in bacterial DNA

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22
Q

MOA of Flucytosine

A

Inhibit thimidylate synthase

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23
Q

Antifungal that inhibit B-glucan synthase decreasing fungal cell wall synthesis

A

Caspofungin
Anidulafungin
Micafungin

24
Q

MOA of Terbinafine

A

Interfere with ergosterol synthesis by inhibiting fungal squalene oxidase

25
Q

Antiviral that inhibit neuraminidase that is causes bronchospasm in asthmatics

26
Q

DOC for African sleeping sickness

A

Melarsoprol

27
Q

Antiviral that doesn’t require thymidine kinase to become active again strains of HSV

A

Cifodovir

Foscarnet

28
Q

Electrolyte abnormality in patients taking Foscarnet

A

Hypocalcemia

29
Q

Nucleoside reverse transcriptase inhibitor that causes bone marrow suppresion as an adverse effect

A

Zidovudine

30
Q

Non nucleoside reverse transcriptase inhibitor that is both a inducer and inhibitor of CYP 450

A

Etravirine

31
Q

Inhibit HBV DNA polymerase

A 
Lamivudine
Adefovir Dipovoxil
Entecavir
Telbivudine
Tenofovir
32
Q

Antiviral that blocks RNA dependent RNA polymerase

33
Q

Antimalarial DOC pregnant patients

34
Q

DOC for Trichinosis

A

Thiabendazole

35
Q

Treatment and prophylaxis for chloroquine resistant P. Falciparum

A

Atovaquone-Proguanil

Atovaquone- disrupt mitchodrial electron transport. Blood and tissue schizonticide

Proguanil- inhibit folate synthesis. Sporonticide

36
Q

Antiviral that inhibit neuraminidase

A

Oseltamivir

Zanamivir

37
Q

DOC for uncomplicated falciparum malaria in Philippines

A

Artemether-Lumentabtine

38
Q

Antiprotozoal DOC for asymptomatic cyst carried of E. histolytica

A

Diloxanide Furoate

39
Q

Ivermectin DOC for

A

Strongyloidiasis

40
Q

Antiprotozoal used only for situation where metronidazole cant be used

41
Q

Albendazole is the DOC for

A

Hydatid disease

42
Q

DOC for severe intestinal and extraintestinal amoebiasis

A

Metronidazole

43
Q

DOC for hookworm and roundworm infections

A

Pyrantel pamoate

Depolarization induced paralysis

Enterobius

44
Q

DOC for prophylaxis and treatment of toxoplasmosis. MOA?

A

Pyrimethamine-sulfadiazine

Sequential blockade lf dihydropteroate synthase(sulfadiazine) and dihydrofolate reductase(pyrimethamine)

45
Q

DOC of Cryptosporidiosis

A

Nitazoxanide

46
Q

DOC for prophylaxis and treatment of Pneumocystosis

A

Co-trimoxazole

47
Q

Antiprotozoal used in the hemolymphatic stage of African sleeping sickness

48
Q

DOC of Chagas disease

A

Nifurtimox

49
Q

DOC for trematodes

A

Praziquantel

50
Q

DOC of Advance West African sleeping sickness

A

Eflornithine

Suicide inhibitor of ornithine decarboxylase

Crosses BBB

51
Q

DOC of Leishmaniasis? Except in what country?

A

Sodium stibogluconate

India

52
Q

2nd gen cephalosporins with disulfiram reaction

A

Cefamandole

Cefotetan

53
Q

DOC for Filariasis

A

Diethylcarbamazine

54
Q

DOC for whipworm infections

A

Mebendazole

Contraindicated in pregnancy

Trichuris

55
Q

Only antibiotic with nasal spray route of administration

A

Pentamidine

56
Q

Antihelminthic that kills scolices and cestode segments but has no effect on ova

A

Niclosamide

aka IRIS JON

57
Q

If you were a cactus why?

A

If not why not?

Breaktime! ?

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