PHARMA AIDS Flashcards
Agents that are important in the:
-preparation
-preservation, &
-storage of pharmaceutical products
-are not API
-have little to NO pharmacological activity
pharmaceutical aids and necessities
adsorb fluids and moisture and keep pharmaceutical products dry
Adsorbents
inert substances and vehicles used in pharmaceutical to dilute and decrease the concentration of the API or increase the bulk of formulation
Diluents
are substances added for overcoming agglomeration of the dispersed particles and for increasing the viscosity of the medium so that particle settle down very slowly
Suspending Agents
substances used in the clarification process
Filter Aids
compound that are used to prevent chemical and physical degradation of liquid or semi-solid preparations against antimicrobial contamination
Preservatives
frequently employed in the conversion of drugs to chemical forms
Acids & Bases
maintain the pH of various formulations within prescribed limits
Buffers
prevent oxidative decomposition of pharmaceutically active components
Antioxidants
primary solvent or liquid phase in most liquid pharmaceutical preparations
Water
used for storage and as dispensing container for most drug products
Glass
Acid forms what in water?
H+
Base forms what in water?
-OH
can donate 2 or more H+ per molecule
Polyprotic acid
can only donate 1 H+ per molecule
Monoprotic acid
Brønsted-Lowry Theory
Acids: H+ donors
Bases: H+ acceptors
substances that can act as an acid or base
Amphoteric
Lewis Theory
Acids: electron pair acceptor
Bases: electron pair donor
- taste sour (lemons, vinegar)
- turn blue litmus paper red.
- solutions: pH <7
- can conduct electricity in solution.
Acids
are strong electrolytes.
Strong acids and bases
- taste bitter and feel slippery.
- turn red litmus paper blue.
- solutions: pH > 7
- can conduct electricity in solution.
Bases
Strong Acids (7):
- HCl (hydrochloric acid)
- HNO3 (nitric acid)
- H2SO4 (sulfuric acid)
- HBr (hydrobromic acid)
- HI (hydroiodic acid)
- HClO3 (chloric acid)
- HClO4 (perchloric acid)
Strong Bases (8):
- LiOH (lithium hydroxide)
- NaOH (sodium hydroxide)
- KOH (potassium hydroxide)
- Ca(OH)2 (calcium hydroxide)
- RbOH (rubidium hydroxide)
- Sr(OH)2 (strontium hydroxide)
- CsOH (cesium hydroxide)
- Ba(OH)2 (barium hydroxide)
is the potential of hydrogen ions.
pH
is the potential of hydroxide ions.
pOH
As pH increases, pOH increases.
As pH decreases, pOH decreases.
TRUE OR FALSE
FALSE
As pH increases, pOH decreases.
As pH decreases, pOH increases.
OFFICIAL INORGANIC ACIDS
- Boric acid (H3BO3)
- Hydrochloric acid (HCl)
- Diluted Hydrochloric acid
- Nitric acid (HNO3)
- Phosphoric acid (H3PO4)
- Diluted Phosphoric acid
- Sulfuric acid
Found in seawaters, certain plants, in nearly all fruits and in some volcanic steam jets.
Uses: Antiseptic, since it is a weak bacteriostatic acid agent; in 2% w/v concentration as eyewash and as buffer in ophthalmic solutions
Boric acid (H3BO3)
Synonyms: Hydrogen borate, Boracic acid, and Orthoboric acid.
Boric acid Available in three crystalline forms:
a. colorless, odorless, pearly scales
b. six-sided triclinic crystals
c. white, odorless powder with a soapy feel
The toxicity of boric acid makes it unfit to be taken orally.
- Prepared/ obtained from NaCl or rock salt
- When hydrogen chloride is dissolved in water it is formed. It is a simple diatomic molecule.
- Use: A pharmaceutical aid as an acidifying agent
Hydrochloric acid (HCl)
Synonyms: Chlorhydric acid,
Spirit of Sea Salt, Muriatic acid
Uses:
1. Aiding in the conversion of pepsinogen into pepsin
and of proteins into peptones;
2. Serves as a gastric antiseptic; and,
3. It is also used in the management of gastric
achlorhydria and hypochlorhydria.
Diluted Hydrochloric acid
is the absence of HCl in the stomach
Achlorhydria
deficiency of HCl production of the stomach
Hypochlorhydria
- Prepared from a mineral or a salt, knowns as Potassium nitrate.
- Colourless but as it gets older it turns into a yellow cast.
- Highly corrosive and toxic.
- Causes severe skin burn.
- Reacts with hydroxides, metals, and oxides to form nitrate salts.
Uses:
* Manufacture of sulfuric acid
* Coal tar dyes and explosives
* Nitrating agent in Pyroxylin USP XVII
* Source of nitrate ion in the preparation of milk of bismuth
* Externally, for the elimination of chancres and warts
Nitric acid (HNO3)
Aqua Fortis, Aqua Fuerte
Synonyms: Spirit of Nitre,
- is a weak acid with the chemical formula H3PO4.
- Present in teeth and bones and helps in metabolic processes
- In its liquid form, it appears as a clear, colourless solution
- In its solid form, it appears as a transparent, crystalline solid
Phosphoric acid (H3PO4)
Synonyms: Orthophosphoric acid, Acido Orthofosforico
- The most important -oxy acid of phosphorus
- Used to make phosphate salts for fertilizers.
- Used in dental cement, albumin derivatives preparation and in the sugar and textile industries.
Phosphoric acid (H3PO4)
Uses:
* A tonic and stimulant to the gastric mucous membranes;
* A synergistic substance to pepsin and acids to the formulation of peptones.
Diluted phosphoric acid
- At higher concentrations, it acts as an oxidizing agent and dehydrating agent.
- A syrupy liquid which is odourless and has no colour.
- Water-soluble and releases heat when dissolved in water.
- Widely used in the manufacturing of fertilizers.
- used in chemical synthesis and wastewater processes.
Sulfuric acid (H2SO4)
OFFICIAL INORGANIC BASES
- Strong Ammonia Solution
- Diluted Ammonia Solution
- Calcium Hydroxide
- Potassium Hydroxide
- Sodium Hydroxide
- Sodium Carbonate
- Soda Lime
- Potassium Bicarbonate
- Sodium Bicarbonate
Uses:
* Bronsted base
* Manifacture of nitric acid and sodium bicarbonate
* Preparation of aromatic spirit and ammonia cal silver nitrate solution
Strong Ammonia Solution (NH4OH)
Synonyms: Ammonium hydroxide, Stronger Ammonia Water
is used to treat or prevent syncope
Aromatic Ammonia Spirit
is an alkaline solution of ammonia cal silver nitrate and is used to test for aldehydes
Tollens’ reagent
- Prepared from strong ammonia solution
- Known as ammonia water or household ammonia
- Employed as circulatory inhalant through inhalation of vapors
Use:
Externally, it is used as counter-irritant agent
Diluted Ammonia Solution (NH4OH)
Preparation: Manufactured from lime or calcium oxide through the addition of water in limited amounts in slaking process, characterized by the avid absorption of water by the oxide lumps, and by the final disintegration into fine powder.
Calcium Hydroxide Ca(OH)2
Synonyms: Slaked lime,
Calcium hydrate