Pharma Flashcards
Name the first generation antihistamine which are sedative
Remember CD3
chlorpheniramine
Diphenhydramine
dimenhydrinate
And doxylamine.
What are the clinical indication for first generation antihistamine?
Allergy
motion sickness
sleep aid.
Name the antihistamine which are less sedative
Loratadine
fexofenadine
desloratadine
cetirizine
Name the anti tussive which doesn’t suppress cough reflex
Guaifenesin (Expectorant-thins respiratory secretions)
Name the anti tussive which antagonizes NMDA glutamate receptors
Dextromethorphan
What is the anti tussive drug which cause serotonin syndrome if adds with serotonergic agents.
Dextromethorphan
What are the nasal decongestant drugs?
Pseudoephedrine
phenylephrine
Name the Pulmonary HTN drugs which causing jaw pain
Prostacyclin analogs (epoprostenol, iloprost)
Name the long acting beta agonist used as a prophylaxis in asthma
Salmeterol
formoterol
What is the first line therapy for chronic asthma?
Inhaled corticosteroid (Fluticasone, budesonide)
Name the Muscarinic antagonists used for asthma
Tiotropium
ipratropium
Name the medicine used for aspirin-induced and exercise-induced asthma
Montelukast
zafirlukast
Important information for Asthma
Anti-lgE monoclonal therapy Used in allergic asthma with increased IgE levels resistant to inhaled steroids and long-acting B2 agonists.
Name the medicine for Androgenetic alopecia (pattern baldness)
Minoxidil (Direct arteriolar vasodilator)
Important information
(blue-tinted vision) due to Phosphodiesterase type 5 inhibitors (Sildenafil)
On which receptor Tamsulosin acts?
Selective for a1A/D receptors (found on prostate) vs vascular a1B receptors.
Name the medicine used to t/m for Prostate carcinoma
Flutamide (Nonsteroidal competitive inhibitor at androgen receptors)
What is the mechanism of action of Ketoconazole To block androgen action?
Inhibits steroid synthesis (inhibits 17,20 desmolase/l 7a-hyd roxylase).
What is the mechanism of action of Spironolactone To block androgen action?
Inhibits steroid binding, 17,20 desmolase/17 alpha hydroxylase
What are clinical use of Danazol?
Endometriosis
hereditary angioedema.
Name the drug which is partial agonist at androgen receptors
Danazol
What are side effects of Danazol?
Weight gain, edema
acne, hirsutism
masculinization, Decreases HDL levels, hepatotoxicity
idiopathic intracranial hypertension.
What are the tocolytics agent?
Beta receptor agonist
CCB (Nifedipine)
NASID (Indomethacin)
What are the clinical uses of Leuprolide?
Remember UP PIE
Uterine fibroids,
precocious puberty
prostate cancer
endometriosis
infertility.