Pharma Flashcards
1
Q
BB selectivity?
A
Table: Beta Blockers Medication Mechanism Propranolol Nonselective β antagonist Nadolol Timolol Pindolol Sotalol Carvedilol Nonselective β and selective α1 antagonist Labetalol Bisoprolol Selective β1 antagonist Betaxolol Esmolol Atenolol Acebutolol Metoprolol
2
Q
The majority of beta blockers are metabolized in the liver via the P450 enzyme system (CYP 2D6) except 3 …
A
Nadolol, atenolol, and esmolol.
Nadolol and atenolol are eliminated unchanged in the urine.
Esmolol is metabolized by red cell esterases, similarly to remifentanil
3
Q
Metabolic effect of epinephrine? is it hypo or hyper K?
A
hyperglycemia, increased free fatty acids, and hypokalemia.
K: is transient hyperkalemia due to increased blood glucose levels. This is followed by a beta-2 receptor-mediated potassium shift into both myocytes and erythrocytes, leading to net result of hypokalemia.
4
Q
opioid that can cause seizures
A
Meperidine is metabolized in the liver to normeperidine, which can cause seizures.
