Pharma Flashcards
- if a receptor has no or few spare receptors, what it is most likely to be?
a. full agonist b. partial agonist c. inverse agonist d. allosteric modulator
b. partial agonist
What is the effect of cocaine on androgenic neuron?
a. storage
b. enzyme inhibition
c. transport
d. reuptake1
d. reuptake1
- Which of the following best describes the pharmacokinetic properties?
a. An orally administered drug is mostly absorbed in the small intestine
b. An antacid will increase the absorption of an acidic drug in the gut
c. The more lipophilic the drug is, the less its partition coefficient
d. The half-life of a drug is not influenced by age
a. An orally administered drug is mostly absorbed in the small intestine*
76. Which of the following inhibits the metabolism of methanol into toxic metabolites? a. Atropin b. Ethanol c. N-acetylcysteine d. Sodium bicarbonate
B. Ethanol
What is a contraindication of bethanecol?
A. peptic ulcer e
b. glaucoma
c. Hypothyroidism
d. paralytic illeus
a. peptic ulcer
- What is the effect of muscarinic antagonists?
a. bradycardia
b. bronchoconstriction
c. increased salivary secretion
d. pupil dilation
d. pupil dilation
- In which condition is bactericidal antibiotic is prefered?
a. Healthy immune system
b. Uncomplicated infection
c. Neutropenia
d. Pneumonococcal pneumonia
c. Neutropenia
81. Why is adjustment of drug dose required for children compared to adults? O a. high water ratio b. high albumins concentration c. high glomerular filtration rate d. high hepatic metabolism
a. high water ratio
- What is the mechanism of action of antibiotics in cancer treatment?
a. Inhibits DNA synthesis & nucleic acid synthesis
b. smth about purine
c. Arrest mitosis
a. Inhibits DNA synthesis & nucleic acid synthesis
- What is the common feature of overdose toxicity and allergic reactions?
a. Dose dependence
b. Drug-receptor interaction
c. Genetic predisposition
d. Risk of mild to fatal reactions
d. Risk of mild to fatal reactions
- What is the role of alkylating agents?
a. DNA cross linking
b. Folic acid inhibition
c. Mitosis spindle disrupters
a. DNA cross linking
- What is the primary nonenzymatic mechanism to terminate NA? vO
A. neuronal uptake 1
B. neuronal uptake 2
A. neuronal uptake 1
87. what does mivacurium act on? 10 a. Nicotinic receptor b. muscarinic receptor c. alpha adrenergic d. beta adrenergic
a. Nicotinic receptor
30s 88. How is tetracycline selectively toxic? A. cell wall composition B. Type of ribosomal subunit C. Folic acid D. Chromosomal
B. Type of ribosomal subunit
- What is pharmacodynamics?
a. ADME
b. what the body does to the drug
c. absorption of the drug
d. the interaction of the drug and receptors
d. the interaction of the drug and receptors
- What would likely to occur if a patient being treated with MAO- inhibitors eats tyramine rich food?
a. Bronchoconstriction
b. Decreased peripheral resistance
c. Hypertension crisis
c. Hypertension crisis
- Which drug interacts with NMB to enhance blockage and cause paralysis?
a. Pilocarpine
b. Bethanechol
c. Gentamicin
d. Latrotoxin
c. Gentamicin
- How to increase the half-life of gentamicin?
a. Decrease glomerular filtration
94. Why do polar drugs have longer half-life in? v0 a. decreased glomerular filtration rate b. decrease Fat stores c. increase alpha1-acid glycoproteins
a. decreased glomerular filtration rate
- What is true about first order kinetics?
a. drug elimination rate is proportional to drug dose
b. graph of drug concentration and time is a straight line
c. elimination rate is same for all doses
a. drug elimination rate is proportional to drug dose
What defines augmented pharmacological effects? A.Normal pharmacological function
B.have to be exposed to drug before
C. unpredictable
D. Irreversible
A.Normal pharmacological function
