pharma 1 Flashcards
First line drug for HTN
( orally )
Diuretics
Side effect of thiazide diuretics
Hypokalemia
Hyperglycemia
What are loop diuretics & what are their side effects ?
Furosemide , ethacrynic acid , bumetanide
Hypokalemia & ototoxicity
Aliskiren
Competitive selective renin inhibitor
Relaxing blood vessels
Not be given in combo with ARBs or ACE1 in patients w diabetes
Aliskiren
mechanism of ACE1
Inhibit formation of Ang ll
Prevent loss of kidney function
Improve insulin sensitivity
Side effects of ACE l
Cough due to onc bradykinin
Mechanism of ARBs
Block ATl receptor
Dec peripheral resistance
CCB
Inhibit entry of calcium ions into vascular smooth muscle cells or myocardial cells
Dihydropyridine : nife & amlo
Vasodilator of arteries & dec peripheral resistance
Do not aafect cardiac function
Non dihydropyridine : verapamil
Dec av & sa nodal conduction
Beta blocker
Lower bp
Dec co
Inhibit renin release
Effective in MI
May lead to bronchospasm
Beta blocker
Alpha 1 blocker ( doxazosin , terazosin)
Reduce vasoconstriction and inc vasodilation
Imp urine flow
Reduce urinary symptoms associated w prostate enlargement
Alpha1 / beta blocking agents ( carve & labeta )
Anti hypertensive due to combined no selective antagonism