pharma 1 Flashcards

1
Q

First line drug for HTN
( orally )

A

Diuretics

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2
Q

Side effect of thiazide diuretics

A

Hypokalemia
Hyperglycemia

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3
Q

What are loop diuretics & what are their side effects ?

A

Furosemide , ethacrynic acid , bumetanide
Hypokalemia & ototoxicity

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4
Q

Aliskiren

A

Competitive selective renin inhibitor
Relaxing blood vessels

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5
Q

Not be given in combo with ARBs or ACE1 in patients w diabetes

A

Aliskiren

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6
Q

mechanism of ACE1

A

Inhibit formation of Ang ll
Prevent loss of kidney function
Improve insulin sensitivity

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7
Q

Side effects of ACE l

A

Cough due to onc bradykinin

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8
Q

Mechanism of ARBs

A

Block ATl receptor
Dec peripheral resistance

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9
Q

CCB

A

Inhibit entry of calcium ions into vascular smooth muscle cells or myocardial cells

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10
Q

Dihydropyridine : nife & amlo

A

Vasodilator of arteries & dec peripheral resistance
Do not aafect cardiac function

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11
Q

Non dihydropyridine : verapamil

A

Dec av & sa nodal conduction

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12
Q

Beta blocker

A

Lower bp
Dec co
Inhibit renin release

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13
Q

Effective in MI
May lead to bronchospasm

A

Beta blocker

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14
Q

Alpha 1 blocker ( doxazosin , terazosin)

A

Reduce vasoconstriction and inc vasodilation
Imp urine flow
Reduce urinary symptoms associated w prostate enlargement

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15
Q

Alpha1 / beta blocking agents ( carve & labeta )

A

Anti hypertensive due to combined no selective antagonism

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16
Q

Contraindication of carvedilol

A

Bronchial asthma
Severe bradycardia

17
Q

Alpha 2 agonists (Alpha-Methyldopa, Clonidine)

A

Prevent release of catecholamines
α-Methyldopa is used to treat pregnancy-induced hypertension.

18
Q

Direct Vasodilators (Hydralazine, Minoxidil, Nitrates (Sodium nitroprusside)

A

decreased peripheral resistance and blood pressure.
swelling in the lower legs.
Minoxidil also may cause excessive hair growth

19
Q

Minoxidil

A

Acts by activating ATP-sensitive potassium channels (has been proven to promote new hair growth in men and women, Regaine /Rogaine).